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CD8/CD16, FITC, PE, clone: 17D8, J5511, Invitrogen™
Antibody Cocktail
Supplier: Interscience Lab Inc 563350
Description
CD8 molecule is composed of two chains termed alpha and beta. CD8 is found on a T cell subset of normal cytotoxic / suppressor cells which make up approximately 20 to 35 % of human peripheral blood lymphocytes. The CD8 antigen is also detected on natural killer cells, 80% of thymocytes, on a subpopulation of 30% of peripheral blood null cells and 15 to 30% of bone marrow cells. CD16 is a 50-65kD cell surface molecule which exists in two forms - a transmembranous form expressed by NK cells and some T cells and a phosphatidylinositol linked form expressed by granulocytes. CD16 is a low affinity receptor for IgG (FcR III), and is an important receptor mediating ADCC by NK cells.
This antibody is a monoclonal mixture of FITC-conjugated CD8 (clone 17D8, isotype IgG1) and PE-conjugated CD16 (clone J5511, isotype IgG1).
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