ChAT Rabbit anti-Human, Mouse, Non-human primate, Rat, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA14738
In Western blot, bands at approximately 68/70 kDa are detected.Choline acetyltransferase is a neuronal enzyme which catalyzes the reaction between Acetyl CoA and choline resulting in the formation of acetylcholine. It is therefore found primarily in cholinergic neurons making it a valuable marker for diseases associated with decreased cholinergic function such as Schizophrenia, Alzheimer disease (AD) and Down syndrome (Holt et al. 1999). Decreased choline acetyltransferase activity in particular has been shown in Schizophrenic subjects (Karson et al 1993). It has furthermore been demonstrated that in patients with AD, there are significantly lower levels of cortical ChAT that correlate with severity of the disease as measured by loss of neuropsychological function (Baskin et al. 1999).
|whole serum with no preservative|
|P28329, Q03059, P32738|
|Human, Mouse, Non-human primate, Rat|
|Immunohistochemistry, Western Blot|
|Native choline acetyltransferase purifed from human placenta|
|-20° C, Avoid Freeze/Thaw Cycles|
|1103, 12647, 290567|
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