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ChAT Rabbit anti-Human, Mouse, Non-human primate, Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA14738

Catalog No. PA14738


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Description

Description

In Western blot, bands at approximately 68/70 kDa are detected.

Choline acetyltransferase is a neuronal enzyme which catalyzes the reaction between Acetyl CoA and choline resulting in the formation of acetylcholine. It is therefore found primarily in cholinergic neurons making it a valuable marker for diseases associated with decreased cholinergic function such as Schizophrenia, Alzheimer disease (AD) and Down syndrome (Holt et al. 1999). Decreased choline acetyltransferase activity in particular has been shown in Schizophrenic subjects (Karson et al 1993). It has furthermore been demonstrated that in patients with AD, there are significantly lower levels of cortical ChAT that correlate with severity of the disease as measured by loss of neuropsychological function (Baskin et al. 1999).
Specifications

Specifications

ChAT
Polyclonal
whole serum with no preservative
P28329, Q03059, P32738
CMS1A, CMS1A2
Rabbit
IgG
RUO
Antibody
Polyclonal
Human, Mouse, Non-human primate, Rat
Immunohistochemistry, Western Blot
Unconjugated
CHAT
Liquid
CHAT
Native choline acetyltransferase purifed from human placenta
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
1103, 12647, 290567
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