Invitrogen™ Complement C4 Monoclonal Antibody (16D2)

Rat Monoclonal Antibody

Supplier:  Invitrogen™ MA140047

Catalog No. 01-676-500

Description

MA1-40047 detects C4 from mouse samples. MA1-40047 has been successfully used in immunohistochemistry (frozen), immunoprecipitation, ELISA, immunofluorescence and Western blot applications. The MA1-40047 immunogen is mouse complement factor C4. Suggested positive Control: T-cell regions of Mouse spleen.

This gene encodes the acidic form of complement factor 4, part of the classical activation pathway. The protein is expressed as a single chain precursor which is proteolytically cleaved into a trimer of alpha, beta, and gamma chains prior to secretion. The trimer provides a surface for interaction between the antigen-antibody complex and other complement components. The alpha chain may be cleaved to release C4 anaphylatoxin, a mediator of local inflammation. Deficiency of this protein is associated with systemic lupus erythematosus and type I diabetes mellitus. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. Varying haplotypes of this gene cluster exist, such that individuals may have 1, 2, or 3 copies of this gene.

Specifications

• Antigen: Complement C4
• Classification: Monoclonal
• Concentration: 100 μg/mL
• Formulation: PBS with 0.1% BSA and 0.02% sodium azide
• Gene Accession No.: P01029
• Gene Symbols: C4A, C4B
• Immunogen: Thymocytes decorated with Thy-1 antibody and complement components.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Mouse
• Product Type: Antibody
• Isotype: IgG2a

• Applications: ELISA, Immunohistochemistry (Frozen), Immunoprecipitation, Western Blot
• Clone: 16D2
• Conjugate: Unconjugated
• Gene: C4B
• Gene Alias: acidic C4; acidic complement C4; Basic complement C4; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 2; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 3; C4; c4 complement; C4-1; C4a; C4a anaphylatoxin; C4A2; C4A3; C4A4; C4A6; C4AD; C4B; C4B_2; C4B1; C4B12; C4B2; C4B3; C4B5; C4b-A; C4b-B; C4BD; C4d-A; C4d-B; C4F; C4S; CH; Chido form of C4; CO4; Complement C4; Complement C4 alpha chain; Complement C4 beta chain; Complement C4 gamma chain; Complement C4-A; Complement C4-A alpha chain; Complement C4-B; Complement C4-B alpha chain; complement C4B1a; complement component 4 (within H-2S); complement component 4, gene 1; complement component 4A (Rodgers blood group); complement component 4B (Chido blood group); complement component 4B (Childo blood group); CPAMD2; CPAMD3; DADB-112B14.11; DAMC-258G8.6; FLJ60561; MGC164979; MHC class III region complement; RG; Rodgers form of C4; sex-limited protein; Slp; Ss
• Host Species: Rat
• Purification Method: Protein G
• Regulatory Status: RUO
• Gene ID (Entrez): 12268, 625018
• Content And Storage: 4°C
• Form: Liquid

Safety and Handling

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