Complement C5a Mouse anti-Human, Clone: 2952, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA140162
MA1-40162 detects C5a/C5a des-Arg from human samples. MA1-40162 has been successfully used in ELISA, Immunohistochemsitry (Frozen, Paraffin), Functional Assays and Western blot applications. The MA1-40162 immunogen is the Neo-epitope on C5a. The MA1-40162 immunogen is the Neo-epitope on C5a (ISHKDMQLG amino acid 65-73). Endotoxin <24 EU/mg. Positive control Human Granulocytes. General comment: Please notice that under given conditions it is known that C5 can expose epitopes normally only found in the cleaved activation productsMonoclonal antibody 2952 reacts with a neo-epitope on C5a (des-Arg) that is formed upon cleavage of C5 into C5a and C5b. C5 is involved in the activation of the lythic pathway within the complement system which is an important factor in innate immunity. The complement pathways can be divided in the activation pathways and lytic pathway. The activation pathways lead via C3 to the cleavage of the fifth complement component C5. C5a induces smooth muscle contraction, increases vascular permeability, causes degranulation of mast cells and basophils, and release of lysosomal enzymes. In addition C5a stimulates the directed migration of neutrophils, eosinophils, basophils and monocytes. Recent studies indicate the modulation of the acute-phase response in liver and an overall immune response by inducing synthesis of cytokines such as TNF-alpha IL-1beta, IL-6 and IL-8.
|PBS with 0.1% BSA and no preservative|
|CPAMD4, FLJ17816, FLJ17822, MGC142298|
|ELISA, Functional Assay, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Western Blot|
|Neo-epitope on C5a.|
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