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Complement C5a Mouse anti-Human, Clone: 2952, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA140162

Catalog No. 01-676-535


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Description

Description

MA1-40162 detects C5a/C5a des-Arg from human samples. MA1-40162 has been successfully used in ELISA, Immunohistochemsitry (Frozen, Paraffin), Functional Assays and Western blot applications. The MA1-40162 immunogen is the Neo-epitope on C5a. The MA1-40162 immunogen is the Neo-epitope on C5a (ISHKDMQLG amino acid 65-73). Endotoxin <24 EU/mg. Positive control Human Granulocytes. General comment: Please notice that under given conditions it is known that C5 can expose epitopes normally only found in the cleaved activation products

Monoclonal antibody 2952 reacts with a neo-epitope on C5a (des-Arg) that is formed upon cleavage of C5 into C5a and C5b. C5 is involved in the activation of the lythic pathway within the complement system which is an important factor in innate immunity. The complement pathways can be divided in the activation pathways and lytic pathway. The activation pathways lead via C3 to the cleavage of the fifth complement component C5. C5a induces smooth muscle contraction, increases vascular permeability, causes degranulation of mast cells and basophils, and release of lysosomal enzymes. In addition C5a stimulates the directed migration of neutrophils, eosinophils, basophils and monocytes. Recent studies indicate the modulation of the acute-phase response in liver and an overall immune response by inducing synthesis of cytokines such as TNF-alpha IL-1beta, IL-6 and IL-8.
Specifications

Specifications

Complement C5a
Monoclonal
0.1 mg/mL
PBS with 0.1% BSA and no preservative
P01031
CPAMD4, FLJ17816, FLJ17822, MGC142298
Mouse
IgG1
100 μg
4° C
Primary
727
ELISA, Functional Assay, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Western Blot
2952
Unconjugated
C5
Liquid
C5
Neo-epitope on C5a.
Protein G
RUO
Antibody
Monoclonal
Human
Documents
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