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CrkL (pY207) Mouse, PE, Clone: K30-391.50.80, BD

Catalog No. BDB560788 Shop All BD Biosciences Products
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BDB560788 50 Tests
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Description

Mouse Monoclonal Antibody

Crk-Like (CrkL) is an adaptor protein that is preferentially expressed in hematopoietic cells and is encoded by a gene that is homologous to the viral oncogene v-crk (chicken tumor virus no. 10 regulator of kinase). Its SH2 and SH3 domains bind to a variety of effector proteins, such as paxillin, p130Cas, c-Cbl, c-Abl, and C3G. These interactions are involved in the regulation of cellular migration, adhesion, and transformation. Tyrosine 207 (Y207) of CrkL is phosphorylated in hematopoietic cells that express the BCR-ABL fusion protein. This site
may be a negative regulator of protein complex formation and biological activity.

Intracellular Staining

TRUSTED_SUSTAINABILITY

Specifications

Antigen CrkL (pY207)
Applications Flow Cytometry
Classification Monoclonal
Clone K30-391.50.80
Conjugate PE
Formulation Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
Host Species Mouse
Immunogen Phosphorylated Human, Mouse, and Rat CrkL Peptide
Purification Method Affinity Purified
Quantity 50 Tests
Regulatory Status RUO
Research Discipline Cell Biology
Primary or Secondary Primary
Target Species Human, Mouse, Rat
Content And Storage Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Isotype IgG2a κ
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