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anti-Cryptococcus neoformans, Clone: CSFi, Lab Vision™

Mouse Monoclonal Antibody

Specifications

Antigen Cryptococcus neoformans Ab-1
Format Purified
Host Species Murine
Immunogen Formalin-treated encapsulated clinical isolate, CSF-1.
Isotype IgG2b
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Products 5
Catalog Number Mfr. No. Concentration Conjugate Quantity Price Quantity & Availability  
Catalog Number Mfr. No. Concentration Conjugate Quantity Price Quantity & Availability  
MS622P
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Epredia
MS622P
200μg/mL Unconjugated 1mL This item has been discontinued by the manufacturer and is no longer available. Please call customer service for assistance: 1-800-766-7000.
N/A
MS622P0
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Epredia
MS622P0
200μg/mL Unconjugated 100μL This item has been discontinued by the manufacturer and is no longer available. Please call customer service for assistance: 1-800-766-7000.
N/A
MS622P1
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Epredia
MS622P1
200μg/mL Unconjugated 500μL This item has been discontinued by the manufacturer and is no longer available. Please call customer service for assistance: 1-800-766-7000.
N/A
MS622P1ABX
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Epredia
MS622P1ABX
1mg/mL Unconjugated 100μL This item has been discontinued by the manufacturer and is no longer available. Please call customer service for assistance: 1-800-766-7000.
N/A
MS622PABX
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Epredia
MS622PABX
1mg/mL Unconjugated 200μL This item has been discontinued by the manufacturer and is no longer available. Please call customer service for assistance: 1-800-766-7000.
N/A
Description

Description

The most important opportunistic fungal pathogens include Cryptococcus neoformans, Candida and Aspergillus species, and the fungi that cause mucormycosis. C. neoformans resides and survives in an acidic phagolysosome. Disseminated cryptococcosis is accompanied by cryptococcal polysaccharides in the serum and the lack of cellular infiltrates in infected tissues. C. neoformans stimulates fetal blood lymphocytes to proliferate and stimulates proliferation of CD45RA+ cells from adults, indicating that it stimulates naive T cells.

Host Species: Mouse
Clone: CSFi
Isotype: IgG2b
Cross Reactivity: All strains of C neoformans
Epitope: Carbohydrate moiety occuring on one or two glycoproteins.
Immunogen: Formalin-treated encapsulated clinical isolate, CSF-1.
Molecular Weight: ~50kDa and ~90kDa
Positive Control: Brain tissue infected with C. neoformans.
Cellular Localization: Cell wall.

Ab-1 binds to glycoproteins with MWs of ~50kDa and ~90kDa found in the yeast cell wall, on its surface, and secreted into the culture medium. Binding of Ab-1 to cell-associated antigens opsonizes the yeast and enhances their phagocytosis. NeoMarkers' Ab-1 identifies all (encapsulated and acapsular) strains of C. neoformans and is suitable for staining of formalin-fixed, paraffin-embedded tissues.

Electron Microscopy, Immunofluorescence, Immunohistochemistry, Western Blotting

Abbreviations: AP=Affinity Purification, ChIP=Chromatin IP, CM=Confocal Microscopy, DB=Dot Blot, EIA=ELISA, EM=Electron Microscopy, FC=Flow Cytometry, GS=Gel Supershift, IC=Immunocytochemistry, IF=Immunofluorescence, IH=Immunohistology/Immunohistochemistry, IP=Immunoprecipitation, IPK=IP Kinase Assay, KA=Kinase Assay, NEUT=Neutralization, PIA=Peptide Inhibition Assay, RIA=Radioimmunossay, TCA=T Cell Activation, WB=Western Blotting, Species: Am=Amphibian, Av=Avian, B=Bovine, Ca=Cat ,Ck=Chicken, D=Dog, Dr=Deer, Ds=Drosophila, El=Elk, Fg=Frog, Fs=Fish, Ft=Ferret, G=Goat, Gp=Guinea Pig, H=Horse, Hm=Hamster, Hu=Human, K=Kangaroo, Ms=Mouse, Nhp=Non-Human Primate, O=Ovine, P=Porcine, Rb=Rabbit, Rp=Reptile, Rt=Rat, Ys=Yeast, Xn=Xenopus, (wk)=cross reacts weakly

Specifications

Specifications

Cryptococcus neoformans Ab-1
Murine
IgG2b
Primary
Purified
Formalin-treated encapsulated clinical isolate, CSF-1.
Monoclonal
SDS
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