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anti-Cryptococcus neoformans, Clone: CSFi, Epredia™ LabVision

Catalog No. p-3037657 Shop All Epredia Products
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Quantity:
100 μL
200 μL
500 μL
1 mL
Concentration:
1mg/mL
200μg/mL
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Catalog No. Quantity Concentration
MS622P0 100 μL 200μg/mL
MS622P1 500 μL 200μg/mL
MS622P 1 mL 200μg/mL
MS622P1ABX 100 μL 1mg/mL
MS622PABX 200 μL 1mg/mL
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Catalog No. MS622P0 Supplier Epredia Supplier No. MS622P0

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Mouse Monoclonal Antibody

The most important opportunistic fungal pathogens include Cryptococcus neoformans, Candida and Aspergillus species, and the fungi that cause mucormycosis. C. neoformans resides and survives in an acidic phagolysosome. Disseminated cryptococcosis is accompanied by cryptococcal polysaccharides in the serum and the lack of cellular infiltrates in infected tissues. C. neoformans stimulates fetal blood lymphocytes to proliferate and stimulates proliferation of CD45RA+ cells from adults, indicating that it stimulates naive T cells.

Host Species: Mouse
Clone: CSFi
Isotype: IgG2b
Cross Reactivity: All strains of C neoformans
Epitope: Carbohydrate moiety occuring on one or two glycoproteins.
Immunogen: Formalin-treated encapsulated clinical isolate, CSF-1.
Molecular Weight: ∽50kDa and ∽90kDa
Positive Control: Brain tissue infected with C. neoformans.
Cellular Localization: Cell wall.

Ab-1 binds to glycoproteins with MWs of ∽50kDa and ∽90kDa found in the yeast cell wall, on its surface, and secreted into the culture medium. Binding of Ab-1 to cell-associated antigens opsonizes the yeast and enhances their phagocytosis. NeoMarkers' Ab-1 identifies all (encapsulated and acapsular) strains of C. neoformans and is suitable for staining of formalin-fixed, paraffin-embedded tissues.

Electron Microscopy, Immunofluorescence, Immunohistochemistry, Western Blotting

Abbreviations: AP=Affinity Purification, ChIP=Chromatin IP, CM=Confocal Microscopy, DB=Dot Blot, EIA=ELISA, EM=Electron Microscopy, FC=Flow Cytometry, GS=Gel Supershift, IC=Immunocytochemistry, IF=Immunofluorescence, IH=Immunohistology/Immunohistochemistry, IP=Immunoprecipitation, IPK=IP Kinase Assay, KA=Kinase Assay, NEUT=Neutralization, PIA=Peptide Inhibition Assay, RIA=Radioimmunossay, TCA=T Cell Activation, WB=Western Blotting, Species: Am=Amphibian, Av=Avian, B=Bovine, Ca=Cat ,Ck=Chicken, D=Dog, Dr=Deer, Ds=Drosophila, El=Elk, Fg=Frog, Fs=Fish, Ft=Ferret, G=Goat, Gp=Guinea Pig, H=Horse, Hm=Hamster, Hu=Human, K=Kangaroo, Ms=Mouse, Nhp=Non-Human Primate, O=Ovine, P=Porcine, Rb=Rabbit, Rp=Reptile, Rt=Rat, Ys=Yeast, Xn=Xenopus, (wk)=cross reacts weakly

Specifications

Antigen Cryptococcus neoformans Ab-1
Classification Monoclonal
Concentration 200μg/mL
Conjugate Unconjugated
Host Species Mouse
Immunogen Formalin-treated encapsulated clinical isolate, CSF-1.
Quantity 100 μL
Primary or Secondary Primary
Form Purified
Isotype IgG2b
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