Learn More
CUL-3 Mouse, Unlabeled, Clone: 3, BD
Mouse Monoclonal Antibody
Supplier: BD Biosciences 611848
Description
The cullins are a family of proteins that are integral to cell cycle regulation. Members of this family include human Cul proteins, C.elegans Ce-Cul-1, and S. cerevisiae Cdc53. Proper control of cell cycle progression is essential for the prevention of tumorigenesis. Mutant forms of both Ce-Cul-1 and Cdc53 have been implicated in the oncogenic process. The human Cul family of proteins, Cul-1, -2, -3, -4A, -4B, and -5, have also been implicated in oncogenic processes. Abnormal nuclear localization of Cul-2 is seen in a rare hereditary condition known as VHL (von Hippel-Lindau) syndrome. Patients with VHL syndrome possess a mutant VHL gene and develop cancers such as retinal anginomas, CNS hemangioblastomas, and renal cell carcinomas. Cul-3 is widely expressed in normal cells and tissues, and shows increased expression in colon cancer cells. Cul-3 can associate with cyclin E in mammalian cells, and overexpression of Cul-3 targets cyclin E for ubiquination, while deletion of Cul-3 in mice leads to increased cyclin E accumulation and abnormal regulation of S-phase. Thus, the Cul
family of proteins may have roles in cell cycle regulation and tumoriogenesis.
Host Species: Mouse
Clone: 3
Isotype: IgG1
Species Reactivity [for Features Main]: Rat
Immunogen: Human CUL-3 aa. 565-684
Immunofluorescence, Western Blotting

Specifications
CUL-3 | |
Monoclonal | |
250μg/mL | |
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide. | |
Human CUL-3 aa. 565-684 | |
50 μg | |
Cell Biology | |
Canine, Chicken, Human, Mouse, Rat | |
IgG1 |
Western Blot | |
3 | |
Unconjugated | |
Mouse | |
Affinity Purified | |
RUO | |
Primary | |
Store undiluted at -20°C. |
Your input is important to us. Please complete this form to provide feedback related to the content on this product.