DOK1, Rabbit, Monoclonal Antibody, Abnova™

Rabbit monoclonal antibody raised against a human DOK1 peptide using ARM Technology.

Supplier:  Abnova Corporation H00001796K

Catalog No. 89-204-818

Includes: Up to three rabbit IgG clones of 1mg each will be delivered to customer.

Description

Docking protein 1 is constitutively tyrosine phosphorylated in hematopoietic progenitors isolated from chronic myelogenous leukemia (CML) patients in the chronic phase. It may be a critical substrate for p210(bcr/abl), a chimeric protein whose presence is associated with CML. Docking protein 1 contains a putative pleckstrin homology domain at the amino terminus and ten PXXP SH3 recognition motifs. Docking protein 2 binds p120 (RasGAP) from CML cells. It has been postulated to play a role in mitogenic signaling. [provided by RefSeq

Library Construction: Nonfusion antibody library from rabbit spleen (ARM Technology)
Expression: Overexpression vector and transfection into 293H cell line

Order Info

1. Customer may provide cell or tissue lysate for antibody screening.
2. Rabbit monoclonal antibody generated by ARM technology is amenable to antibody engineering including F(ab)2, IgG, scFv and different Fc and non-Fc conjugates per customer request.

Specifications

• Antigen: DOK1
• Classification: Monoclonal
• Conjugate: Unconjugated
• Formulation: In 1X PBS, pH 7.4
• Gene Accession No.: DOK1
• Gene Symbols: DOK1
• Immunogen: A synthetic peptide of human DOK1
• Regulatory Status: RUO
• Gene ID (Entrez): 1796
• Content And Storage: Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
• Isotype: IgG

• Applications: ELISA, Western Blot
• Concentration: 1mg
• Description: docking protein 1, 62kDa (downstream of tyrosine kinase 1)
• Gene: DOK1
• Gene Alias: MGC117395, MGC138860, P62DOK
• Host Species: Rabbit
• Quantity: 1 mg x up to 3 Abs
• Primary or Secondary: Primary
• Target Species: Human
• Form: Liquid