Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
  1. Home
  2. Products
  3. Antibodies
  4. Primary Antibodies
  5. All Primary Antibodies
  6. PIPA520841

Invitrogen™ FRMPD4 Polyclonal Antibody
GREENER_CHOICE

Catalog No. PIPA520841
Change view
Click to view available options
Quantity:
100 μg
1 product options available for selection
Product selection table with 1 available options. Use arrow keys to navigate and Enter or Space to select.
Catalog No. Quantity
PIPA520841 100 μg
Use arrow keys to navigate between rows. Press Enter or Space to select a product option. 1 options available.
1 options
Catalog No. PIPA520841 Supplier Invitrogen™ Supplier No. PA520841
Only null left
Add to Cart
Add to Cart

Description

Rabbit Polyclonal Antibody

A suggested positive control is SK-N-SH cell lysate. PA5-20841 can be used with blocking peptide PEP-0955.

The FERM and PDZ domain containing (FRMPD) protein family consists of four proteins that contain a FERM (Four-point-one, erzin, radixin, moesin) domain and at least one PDZ (PSD-95/Discs large/Zonula-occuldens-1) domain. FRMPD4, also known as Preso, also contains another protein interaction domain termed WW (domain with two conserved Trp residues) at its amino terminus. It was identified through a yeast two-hybrid screen using the PDZ domain of PSD-95 as bait and is highly expressed in multiple regions of the brain and is enriched in the postsynaptic density (PSD) fractions. Overexpression of FRMPD4 in cultured hippocampal neurons significantly increased the linear density of dendritic spines without changing their length and width; conversely, knockdown experiments using RNAi caused a decrease in spine density, indicating FRMPD4 positively regulates dendritic spine density but not morphology. The decreased level of FRMPD4 also resulted in reduced levels of excitatory synaptic transmission, suggesting that FRMPD4 is required for maintenance of excitatory synaptic transmission.
TRUSTED_SUSTAINABILITY

Specifications

Antigen FRMPD4
Applications Immunohistochemistry, Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% sodium azide
Gene FRMPD4
Gene Accession No. Q14CM0
Gene Alias FERM and PDZ domain containing 4; FERM and PDZ domain-containing protein 4; FRMPD4; KIAA0195; KIAA0316; PDZ domain-containing protein 10; PDZD10; PDZK10; Preso; PSD-95-interacting FERM and PDZ domain protein; PSD-95-interacting regulator of spine morphogenesis; TMEM94; Transmembrane protein 94
Gene Symbols FRMPD4
Host Species Rabbit
Immunogen An 18 amino acid peptide from near the center of human FRMPD4.
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 9758
Target Species Human
Content And Storage 4°C
Product Type Antibody
Form Liquid
Isotype IgG
Show More Show Less

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
Product Title
Select an issue

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.