Invitrogen™ PSMD10 Polyclonal Antibody

Catalog No.	Quantity
01-950-151	100 μL

Catalog No. 01-950-151 Supplier Invitrogen™ Supplier No. PA116904

Description

Rabbit Polyclonal Antibody

Suggested positive control: Hela whole cell extract, antigen standard for PSMD10 (transient overexpression lysate). Predicted to react with mouse, rat, porcine, bovine, and zebrafish based on 100% sequence homology.

The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a non-ATPase subunit of the 19S regulator. Two transcripts encoding different isoforms have been described. Pseudogenes have been identified on chromosomes 3 and 20.

Specifications

• Antigen: PSMD10
• Applications: Flow Cytometry, Western Blot, Immunocytochemistry
• Classification: Polyclonal
• Concentration: 0.97 mg/mL
• Conjugate: Unconjugated
• Formulation: TBS with 0.05% sodium azide
• Gene: PSMD10
• Gene Accession No.: O75832
• Gene Alias: 26S proteasome non-ATPase regulatory subunit 10; 26S proteasome regulatory subunit p28; ankyrin repeat protein; AW554874; dJ889N15.2; Gankyrin; hepatocellular carcinoma-associated protein p28-II; p28; p28(GANK); p28Gank; proteasome (prosome, macropain) 26S subunit, non-ATPase, 10; proteasome 26S subunit, non-ATPase 10; proteasome subunit p28; proteosome (prosome, macropain) 26S subunit, non-ATPase, 10; proteosome subunit p28; PSMD10
• Gene Symbols: PSMD10
• Host Species: Rabbit
• Immunogen: A synthetic peptide made to an internal portion of the human Gankyrin protein sequence (between residues 100-200).
• Purification Method: Antigen affinity chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 5716
• Target Species: Human
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG