GSK-3b (pY216) Mouse, Unlabeled, Clone: 13A, BD

Catalog No.	Quantity
BDB612313	150 μg
BDB612312	50 μg

Catalog No. BDB612313 Supplier BD Biosciences Supplier No. 612313

Description

Mouse Monoclonal Antibody

Glycogen Synthase Kinase-3β (GSK-3β) is a serine/threonine kinase that affects glycogen metabolism by phosphorylating and down-regulating the activity of muscle glycogen synthase. GSK-3β is identical to the Tau Protein Kinase I (TPK I) that plays a role in the formation of the histopathological brain lesions of Alzheimer's disease (AD). Phosphorylation of the cytoskeletal protein, tau, by GSK-3β converts these proteins into paired helical filaments (PHF) which are found in the neurofibrillary tangles and degenerative neurites of AD patients. Regulation of GSK-3β activity through both serine and tyrosine phosphoylation is a critical determinant of cell death or survival. Factors that promote cell survival, such as growth factors, activate Akt which, in turn phosphorylates GSK-3β at Ser-9, leading to inactivation of its kinase activity. On the contrary, events that promote cell death, such as growth factor removal, cause increases in phosphorylation within the catalytic domain at Tyr-216 and stimulate kinase activity. Thus GSK-3β is a tightly regulated death promoting kinase that regulates the activity of various proteins, including cytokeletal and enzymatic proteins.

Western Blotting

Specifications

• Antigen: GSK-3b (pY216)
• Applications: Western Blot
• Classification: Monoclonal
• Clone: 13A
• Concentration: 250μg/mL
• Conjugate: Unconjugated
• Formulation: Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
• Host Species: Mouse
• Immunogen: Rat GSK-3β (pY216) Peptide
• Purification Method: Affinity Purified
• Quantity: 150 μg
• Regulatory Status: RUO
• Research Discipline: Cell Biology
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Content And Storage: Store undiluted at -20°C.
• Isotype: IgG1

For Research Use Only.