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MilliporeSigma™ anti-HNF-1-beta Clone: 12A5.1,

Catalog No. MABE971MI Shop All MilliporeSigma Products
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Quantity:
100 μg
Conjugate:
Unconjugated
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Catalog No. Quantity Conjugate
MABE971MI 100 μg Unconjugated
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Catalog No. MABE971MI Supplier MilliporeSigma™ Supplier No. MABE971
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Description

Mouse Monoclonal Antibody

Specifically detects HNF-1-beta Clone: 12A5.1 in Human, Rat samples, and it is validated for Immunohistochemistry, Western Blotting

Hepatocyte nuclear factor 1-beta (UniProt P35680; also known as HNF-1-beta, HNF-1B, Homeoprotein LFB3, TCF-2, Transcription factor 2, Variant hepatic nuclear factor 1, vHNF1) is encoded by the HNF1B (also known as TCF2, VHNF1) gene (Gene ID 6928) in human. HNF-1-beta is involved in transcriptional and functional regulation of the liver and biliary system, as well as of the kidneys, urogenital tract and pancreatic β-cells. HNF-1-beta deficiency due to HNF1B mutations is a well known cause of maturity-onset diabetes of the young 5 (MODY5), also referred to as RCAD (renal cysts and diabetes) due to the frequent co-occurrence of renal cysts and/or other inborn urogenital abnormalities. HNF-1-beta is expressed in the gall bladder, liver and intrahepatic bile ducts of mouse embryos and in liver of adult mice. HNF-1-beta is shown to co-regulate morphogenesis of the biliary system and HNF1B knockout mice suffer from severe neonatal cholestasis and jaundice due to the abnormally developed gall bladder and dysfunctional intrahepatic bile ducts.
TRUSTED_SUSTAINABILITY

Specifications

Antigen HNF-1-beta
Applications Immunohistochemistry, Western Blot
Classification Monoclonal
Clone 12A5.1
Conjugate Unconjugated
Formulation Purified mouse monoclonal IgG2aκ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Accession No. P35680
Gene Symbols HNF1B, TCF2
Host Species Mouse
Immunogen GST-tagged recombinant protein corresponding to the Internal (N-terminal half) of human HNF-1-beta.
Purification Method Protein G purified
Quantity 100 μg
Regulatory Status RUO
Research Discipline Epigenetics, Nuclear Function
Primary or Secondary Primary
Gene ID (Entrez) NP_000449
Test Specificity Expected to react with isoform 1 (A) and isoform 3 (C). Reactivity toward isoform 2 (B) and isoform 4 has not been determined.
Target Species Human, Rat
Content And Storage 2°C to 8°C for one year from date of shipment
Form Purified
Isotype IgG2a κ
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For Research Use Only

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