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MilliporeSigma™ anti-HNF-1-beta Clone: 12A5.1,
Mouse Monoclonal Antibody
Supplier: MilliporeSigma™ MABE971
Description
Specifically detects HNF-1-beta Clone: 12A5.1 in Human, Rat samples, and it is validated for Immunohistochemistry, Western Blotting
Hepatocyte nuclear factor 1-beta (UniProt P35680; also known as HNF-1-beta, HNF-1B, Homeoprotein LFB3, TCF-2, Transcription factor 2, Variant hepatic nuclear factor 1, vHNF1) is encoded by the HNF1B (also known as TCF2, VHNF1) gene (Gene ID 6928) in human. HNF-1-beta is involved in transcriptional and functional regulation of the liver and biliary system, as well as of the kidneys, urogenital tract and pancreatic β-cells. HNF-1-beta deficiency due to HNF1B mutations is a well known cause of maturity-onset diabetes of the young 5 (MODY5), also referred to as RCAD (renal cysts and diabetes) due to the frequent co-occurrence of renal cysts and/or other inborn urogenital abnormalities. HNF-1-beta is expressed in the gall bladder, liver and intrahepatic bile ducts of mouse embryos and in liver of adult mice. HNF-1-beta is shown to co-regulate morphogenesis of the biliary system and HNF1B knockout mice suffer from severe neonatal cholestasis and jaundice due to the abnormally developed gall bladder and dysfunctional intrahepatic bile ducts.
Specifications
HNF-1-beta | |
Monoclonal | |
Unconjugated | |
P35680 | |
Mouse | |
Protein G purified | |
RUO | |
Primary | |
Expected to react with isoform 1 (A) and isoform 3 (C). Reactivity toward isoform 2 (B) and isoform 4 has not been determined. | |
2°C to 8°C for one year from date of shipment | |
IgG2a κ |
Immunohistochemistry, Western Blot | |
12A5.1 | |
Purified mouse monoclonal IgG2aκ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide. | |
HNF1B, TCF2 | |
GST-tagged recombinant protein corresponding to the Internal (N-terminal half) of human HNF-1-beta. | |
100 μg | |
Epigenetics, Nuclear Function | |
NP_000449 | |
Human, Rat | |
Purified |
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Product Title
For Research Use Only
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