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Hsp60 Mouse, Unlabeled, Clone: 24/HSP60, BD

Mouse Monoclonal Antibody

$220.00 - $435.00

Specifications

Antigen Hsp60
Isotype IgG1
Immunogen Human Hsp60 aa. 1-200
Formulation Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Conjugate Unconjugated
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Products 2
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
BDB611562
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BD Biosciences
611562
50μg
Each for $220.00
Add to cart
 
BDB611563
View Documents
BD Biosciences
611563
150μg
Each for $435.00
Add to cart
 
Description

Description

Heat shock proteins (Hsp) are a set of highly conserved proteins that include constitutively expressed (Hsp60, Hsp70, and Hsp90) and stress-induced (Hsp27 and Hsp72) proteins. Hsp60 is localized to the mitochondria, where it promotes mitochondrial protein folding and facilitates proteolytic degradation of misfolded or denatured proteins. It binds Hsp10, which regulates the substrate binding and ATPase activity of Hsp60. In HeLa and Jurkat mitochondria, Hsp60 associates with caspase-3 to form a complex that dissociates and releases from the mitochondria during apoptosis. In addition, Hsp60 accelerates the maturation of procaspase-3 through its ATP-dependent “foldase” activity. In addition to its role in protein folding, Hsp60 has also been implicated in immune function. In macrophages, its binding to the toll-like receptor-4 complex induces production of TNFα and nitric oxide and stimulation of a proinflammatory response. Thus, the protein folding function of Hsp60 is involved in mitochondrial protein folding in both normal and apoptotic cells, while release of Hsp60 during necrosis is thought to stimulate a proinflammatory response.

Host Species: Mouse
Clone: 24
Isotype: IgG1
Species Reactivity: Human
Immunogen: Human Hsp60 aa. 1-200
Formula Weight [Chemical]: 60kDa

Immunofluorescence, Western Blotting

Specifications

Specifications

Hsp60
Human Hsp60 aa. 1-200
Unconjugated
Cell Biology
Murine
Affinity Purified
Monoclonal
Store undiluted at -20°C.
IgG1
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Primary
Western Blot
RUO
24/HSP60
250μg/mL
SDS

For Research Use Only.

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