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Invitrogen™ IHOG Monoclonal Antibody (3G8)
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Catalog No. PIMA515648
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100 μL
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PIMA515648 100 μL
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Catalog No. PIMA515648 Supplier Invitrogen™ Supplier No. MA515648
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Description

Mouse Monoclonal Antibody

MA5-15648 targets IHOG in indirect ELISA, WB applications and shows reactivity with Drosophila samples. The MA5-15648 immunogen is purified recombinant fragment of human IHOG expressed in E. Coli. MA5-15648 detects IHOG which has a predicted molecular weight of approximately 98kDa.

The ihog gene (interference hedgehog), identified by RNA interference in Drosophila cultured cells, encodes a type 1 membrane protein shown here to bind and to mediate response to the active Hedgehog (Hh) protein signal. ihog mutations produce defects characteristic of Hh signaling loss in embryos and imaginal discs, and epistasis analysis places ihog action at or upstream of the negatively acting receptor component, Patched (Ptc). The first of two extracellular fibronectin type III (FNIII) domains of the Ihog protein mediates a specific interaction with Hh protein in vitro, but the second FNIII domain is additionally required for in vivo signaling activity and for Ihog-enhanced binding of Hh protein to cells coexpressing Ptc. Other members of the Ihog family, including Drosophila Boi and mammalian CDO and BOC, also interact with Hh ligands via a specific FNIII domain, thus identifying an evolutionarily conserved family of membrane proteins that function in Hh signal response.
TRUSTED_SUSTAINABILITY

Specifications

Antigen IHOG
Applications ELISA, Western Blot
Classification Monoclonal
Clone 3G8
Concentration Conc. Not Determined
Conjugate Unconjugated
Formulation ascites with 0.03% sodium azide
Gene ihog
Gene Accession No. Q9VM64
Gene Alias CG9211; CG9211-PA; CT26314; Dmel\ ihog; Dmel\CG9211; Dmel_CG9211; GH03927p; Ihog; ihog-PA; interference hedgehog
Gene Symbols ihog
Host Species Mouse
Immunogen Purified recombinant fragment of human IHOG expressed in E. Coli.
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 33972
Target Species Human, Drosophila
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG1
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