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IL-1β Mouse anti-Human, Unlabeled, Clone: AS10, BD

Catalog No. BDB550007 Shop All BD Biosciences Products
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BDB550007 0.25 mg
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Catalog No. BDB550007 Supplier BD Biosciences Supplier No. 550007
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Description

Mouse Monoclonal Antibody

The AS10 antibody reacts with human interleukin-1β (IL-1β) which is also known as endogenous pyrogen (EP), leukocyte endogenous mediator (LEM), mononuclear cell factor (MCF) and lymphocyte-activating factor (LAF). IL-1β is a proinflammatory cytokine that is synthesized as a precursor of 31kDa and is converted intracellularly to the mature 17.5kDa form, after cleavage by the IL-1β-converting enzyme (ICE). In healthy individuals, IL-1β is secreted non-constitutively by blood monocytes, tissue macrophages and dendritic cells. IL-1β is also constitutively expressed in the human hypothalamus. Many malignant tumors express IL-1β as part of their neoplastic nature. The immunogen used to generate the AS10 hybridoma was recombinant human E. Coli-expressed recombinant IL-1β. The AS10 antibody does not cross react with mouse IL-1β. This is a neutralizing antibody.

TRUSTED_SUSTAINABILITY

Specifications

Antigen IL-1β
Applications Immunocytochemistry
Classification Monoclonal
Clone AS10
Concentration 0.5mg/mL
Conjugate Unconjugated
Formulation Aqueous buffered solution containing ≤0.09% sodium azide.
Host Species Mouse
Immunogen Recombinant human IL-1β
Purification Method Affinity Purified
Quantity 0.25 mg
Regulatory Status RUO
Research Discipline Immunology
Primary or Secondary Primary
Target Species Human
Content And Storage Store undiluted at 4°C
Isotype IgG1 κ
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For Research Use Only.

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