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JAK1 Mouse, Unlabeled, Clone: 73, BD

Mouse Monoclonal Antibody

$232.00 - $458.00

Specifications

Antigen JAK1
Isotype IgG2b, κ
Immunogen Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Formulation Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Conjugate Unconjugated
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Products 2
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
BDB610232
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BD Biosciences
610232
150μg
Each for $458.00
Add to cart
 
BDB610231
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BD Biosciences
610231
50μg
Each for $232.00
Add to cart
 
Description

Description

The JAK family of receptor-associated protein kinases is directly involved in interferon (IFN) response pathways. The JAK family contains at least three members: JAK1, JAK2, and Tyk2. Each protein is approximately 130kDa and contains a C-terminal tyrosine kinase domain, an adjacent kinase or kinase-related domain, and five other domains that are highly conserved among family members. In several human and murine cell lines, JAK1 is rapidly tyrosine phosphorylated in response to IFN-α and IFN-γ. JAK1 is required for the phosphorylation of the transcription factor Stat1 (p91), in response to IFNs-α or IFN-γ. JAK1 is also necessary for the efficient phophorylation of Stat2 (p113) in response to IFN-α and for the phosphorylation of Tyk2 or JAK2 in response to IFNs-α or IFN-γ, respectively.

Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Western Blotting

Specifications

Specifications

JAK1
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Unconjugated
Cell Biology
Mouse
Affinity Purified
Monoclonal
Store undiluted at -20°C.
IgG2b, κ
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Primary
Western Blot
RUO
73
250μg/mL
SDS
Product Certifications

For Research Use Only.

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