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  6. LEDGF (Lens Epithelium-Derived Growth Factor) Mouse anti-Human, Unlabeled, Clone: 26, BD

LEDGF (Lens Epithelium-Derived Growth Factor) Mouse anti-Human, Unlabeled, Clone: 26, BD

Catalog No. BDB611714 Shop All BD Biosciences Products
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BDB611714 50 μg
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Catalog No. BDB611714 Supplier BD Biosciences Supplier No. 611714

Description

Mouse Monoclonal Antibody

p52/p75 proteins were first identified through their interaction with transcriptional factors and splicing factors. p75 is encoded by exons 1-15 and contains 530 amino acids, while the alternatively spliced p52 is encoded by exons 1-9 and contains 333 amino acids. Both p52 and p75 have strong interactions with the VP16 activation domain and with various components of the general transcriptional machinery. p52 is the more active transcription activator and has also been shown to recruit the pre-mRNA splicing factor ASF/SF to sites of active transcription. Interestingly, p52/p75 has also been identified as Lens Epithelium-Derived Growth Factor (LEDGF). In serum free media, LEDGF stimulates the growth and survival of a variety of cells, such as lens epithelial cells, retinal photoreceptor cells, COS7 cells, skin fibroblasts, and keratinocytes. In retinal photoreceptor cells, LEDGF is found in the nucleus where it promotes resistance to serum starvation and thermal stress. Thus, the LEDGF gene encodes splice variants that may regulate gene transcription and mRNA splicing of a variety of proteins that are essential for cell growth and survival.

Host Species: Mouse
Clone: 26
Isotype: IgG1
Species Reactivity [for Features Main]: Human
Immunogen: Human LEDGF aa. 85-188

Immunofluorescence, Western Blotting

TRUSTED_SUSTAINABILITY

Specifications

Antigen LEDGF (Lens Epithelium-Derived Growth Factor)
Applications In vitro Assay, Western Blot
Classification Monoclonal
Clone 26
Concentration 250μg/mL
Conjugate Unconjugated
Description Lens Epithelium-Derived Growth Factor
Formulation Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Host Species Mouse
Immunogen Human LEDGF aa. 85-188
Purification Method Affinity Purified
Quantity 50 μg
Regulatory Status RUO
Research Discipline Cell Biology
Primary or Secondary Primary
Target Species Human
Content And Storage Store undiluted at -20°C.
Isotype IgG1
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For Research Use Only.

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