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LEDGF (Lens Epithelium-Derived Growth Factor) Mouse anti-Human, Unlabeled, Clone: 26, BD

Mouse Monoclonal Antibody

$225.00 - $445.00

Specifications

Antigen LEDGF (Lens Epithelium-Derived Growth Factor)
Isotype IgG1
Immunogen Human LEDGF aa. 85-188
Formulation Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Conjugate Unconjugated
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Products 2
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
BDB611714
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BD Biosciences
611714
50μg Each for $225.00
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BDB611715
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BD Biosciences
611715
150μg Each for $445.00
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Description

Description

p52/p75 proteins were first identified through their interaction with transcriptional factors and splicing factors. p75 is encoded by exons 1-15 and contains 530 amino acids, while the alternatively spliced p52 is encoded by exons 1-9 and contains 333 amino acids. Both p52 and p75 have strong interactions with the VP16 activation domain and with various components of the general transcriptional machinery. p52 is the more active transcription activator and has also been shown to recruit the pre-mRNA splicing factor ASF/SF to sites of active transcription. Interestingly, p52/p75 has also been identified as Lens Epithelium-Derived Growth Factor (LEDGF). In serum free media, LEDGF stimulates the growth and survival of a variety of cells, such as lens epithelial cells, retinal photoreceptor cells, COS7 cells, skin fibroblasts, and keratinocytes. In retinal photoreceptor cells, LEDGF is found in the nucleus where it promotes resistance to serum starvation and thermal stress. Thus, the LEDGF gene encodes splice variants that may regulate gene transcription and mRNA splicing of a variety of proteins that are essential for cell growth and survival.

Host Species: Mouse
Clone: 26
Isotype: IgG1
Species Reactivity [for Features Main]: Human
Immunogen: Human LEDGF aa. 85-188

Immunofluorescence, Western Blotting

Specifications

Specifications

LEDGF (Lens Epithelium-Derived Growth Factor)
Human LEDGF aa. 85-188
Unconjugated
Cell Biology
Murine
Affinity Purified
Monoclonal
Lens Epithelium-Derived Growth Factor
IgG1
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Primary
In vitro Assay, Western Blot
RUO
26
250μg/mL
Store undiluted at -20°C.

For Research Use Only.

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