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LR11 [SorLA; gp250; Lipoprotein Receptor-11] Mouse, Unlabeled, Clone: 48, BD

Catalog No. BDB612633 Shop All BD Biosciences Products
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BDB612633 50 μg
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Catalog No. BDB612633 Supplier BD Biosciences Supplier No. 612633
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Description

Mouse Monoclonal Antibody

The low-density lipoprotein receptor (LDLR) functions in lipoprotein transport pathways, and is involved in familial hypercholesterolemia. Homologues of the LDLR may have diverse functions and their ligands may include biological inactive plasma carrier complexes, plasma lipoproteins, yolk precursors, toxins, and extracellular lipoproteins. LR11 (also known as sorLA-1 and gp250) is a lipoprotein receptor homologue that contains 11 LDL receptor ligand binding repeats (LDLRs), 5 LDL receptor “YWTD”repeats, a large fibronectin-type III (FIII) hexarepeat domain similar to neural adhesion proteins, and a domain with similarity to the yeast receptor for vacuolar protein sorting (Vsp10p). LR11mRNA is expressed at high levels in brain, but is also found in liver, pancreas, adrenal gland, and testis. LR11 can bind the ER and Golgi localized receptor associated protein (RAP), which binds to many members of the LDLR family and prevents aggregation of ligands to the LDLRs. In addition, LR11 binds apolipoprotein E-containing lipoproteins. Thus, LR11 is a lipoprotein binding receptor that may have additional functions related to protein sorting and neuronal development.

Immunofluorescence, Immunohistochemistry, Western Blotting

TRUSTED_SUSTAINABILITY

Specifications

Antigen LR11 [SorLA; gp250; Lipoprotein Receptor-11]
Applications Western Blot
Classification Monoclonal
Clone 48
Concentration 250μg/mL
Conjugate Unconjugated
Description SorLA; gp250; Lipoprotein Receptor-11
Formulation Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Host Species Mouse
Immunogen Human LR11 aa. 1220-1337
Purification Method Affinity Purified
Quantity 50 μg
Regulatory Status RUO
Research Discipline Cell Biology
Primary or Secondary Primary
Target Species Fly, Human, Mouse, Rat
Content And Storage Store undiluted at -20°C.
Isotype IgG2a
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