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MARCH8 Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA520632

Catalog No. PIPA520632


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Description

Description

A suggested positive control is Hela cell lysate. PA5-20632 can be used with blocking peptide PEP-0752.

MARCH8 (c-MIR) is a novel E3 ubiquitin ligase designated as the modulator of immune recognition (MIR) family, whose catalytic domain is a variant RING domain (RING-CH domain). MARCH8 was found as a functional and structural homolog of KSHV MIR1 and MIR2. MARCH8 targets B7-2 to lysosomal degradation and down-regulates the B7-2 surface expression through ubiquitination of its cytoplasmic tail. Furthermore, MARCH8 has been shown to down-regulate the expression of transferrin receptor and Fas, an important molecule for the induction of apoptosis. MARCH8 is the first example of an E3 ubiquitin ligase that is capable of inhibiting MHC II expression. Recent findings suggest that MARCH8 may regulate immune responses by promoting ubiquitination of MHC-II and CD86, leading to their subsequent endocytosis and lysosomal degradation.
Specifications

Specifications

MARCH8
Polyclonal
Unconjugated
MARCH8
Liquid
MARCH8
A 17 amino acid peptide from near the carboxy terminus of human MARCH8.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse, Rat
Immunocytochemistry, Western Blot
1 mg/mL
PBS with 0.02% sodium azide
Q5T0T0, Q9DBD2
RP11-67C2.1, MARCH-VIII, MIR, RNF178, c-MIR; E3 ubiquitin-protein ligase MARCH8; RING finger protein 178; c-mir, cellular modulator of immune recognition; cellular modulator of immune recognition (c-MIR); membrane-associated RING finger protein 8; membrane-associated RING-CH protein VIII
Rabbit
IgG
100 μg
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Primary
220972, 312656, 71779
Documents
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