MARCH8 Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA520632
A suggested positive control is Hela cell lysate. PA5-20632 can be used with blocking peptide PEP-0752.MARCH8 (c-MIR) is a novel E3 ubiquitin ligase designated as the modulator of immune recognition (MIR) family, whose catalytic domain is a variant RING domain (RING-CH domain). MARCH8 was found as a functional and structural homolog of KSHV MIR1 and MIR2. MARCH8 targets B7-2 to lysosomal degradation and down-regulates the B7-2 surface expression through ubiquitination of its cytoplasmic tail. Furthermore, MARCH8 has been shown to down-regulate the expression of transferrin receptor and Fas, an important molecule for the induction of apoptosis. MARCH8 is the first example of an E3 ubiquitin ligase that is capable of inhibiting MHC II expression. Recent findings suggest that MARCH8 may regulate immune responses by promoting ubiquitination of MHC-II and CD86, leading to their subsequent endocytosis and lysosomal degradation.
|A 17 amino acid peptide from near the carboxy terminus of human MARCH8.|
|Antigen affinity chromatography|
|Human, Mouse, Rat|
|Immunocytochemistry, Western Blot|
|PBS with 0.02% sodium azide|
|RP11-67C2.1, MARCH-VIII, MIR, RNF178, c-MIR; E3 ubiquitin-protein ligase MARCH8; RING finger protein 178; c-mir, cellular modulator of immune recognition; cellular modulator of immune recognition (c-MIR); membrane-associated RING finger protein 8; membrane-associated RING-CH protein VIII|
|Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C|
|220972, 312656, 71779|
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