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mGluR1 Mouse, Unlabeled, Clone: 20, BD

Mouse Monoclonal Antibody

$207.00 - $415.00

Specifications

Antigen mGluR1
Isotype IgG1
Immunogen Rat mGluR1 aa. 1042-1160
Formulation Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Conjugate Unconjugated
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Products 2
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
BDB610965
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BD Biosciences
610965
150μg Each for $415.00
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BDB610964
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BD Biosciences
610964
50μg Each for $207.00
Add to cart
 
Description

Description

Glutamate is a major excitatory neurotransmitter and functions in multiple roles in the CNS. The functional diversity of glutamate is exemplified by two distinct groups of glutamate receptors: ionotropic and metabotropic. Coupling with G proteins provides the metabotropic glutamate receptors (mGluRs) with the capacity for intracellular signal transduction. Eight metabotropic glutamate receptors (mGluR1-8) and several Ca2+ sensing receptors belong to a novel G-protein coupled receptor (GPCR) family. The mGluRs possess the seven putative transmembrane domains which are characteristic of GPCR proteins. However, they exhibit no additional sequence homology to any member of other GPCR families. mGluR1 has large hydrophilic sequences in both the N- and C-terminal sides of the seven transmembrane domains. The sizable extracellular N-terminal domain is homologous to bacterial periplasmic binding proteins and serves as the glutamate binding site. mGluR1 activates phospholipase C (PLC), resulting in phosphoinositide turnover and, in turn, Ca2+; mobilization necessary for many signal transduction events.

Immunofluorescence, Western Blotting

Specifications

Specifications

mGluR1
Rat mGluR1 aa. 1042-1160
Unconjugated
Cell Biology
Murine
Affinity Purified
Monoclonal
Metabotropic Glutamate Receptor-1
IgG1
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Primary
Western Blot
RUO
20
250μg/mL
Store undiluted at -20°C.

For Research Use Only.

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