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MilliporeSigma™ anti-MYH (33-51), Polyclonal

Catalog No. PC709100UL Shop All MilliporeSigma Products
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Quantity:
100 μL
Conjugate:
Unconjugated
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Catalog No. Quantity Conjugate
PC709100UL 100 μL Unconjugated
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Catalog No. PC709100UL Supplier MilliporeSigma™ Supplier No. PC709100UL

Description

Rabbit Polyclonal Antibody

Specifically detects MYH (33-51) Clone: in Human, Rat samples, and it is validated for Immunofluorescence, Immunohistochemistry (Paraffin)

Oxidative DNA base lesions such as 8-oxoguanine (8-oxoG) are frequently mutagenic and have been implicated in a variety of pathophysiological states including cancer, Alzheimer's disease, arthritis, and cardiovascular disease. These lesions are generated by oxidative stress. MYH is a mammalian homolog of theE. coli Mut Y DNA glycosylase that excises adenine residues misincorporated opposite the oxidized base, 8-oxoG. MYH up-regulation can be observed following damage in mitochondrial DNA. Single mutations in this protein result in reduced translation efficiency of transcripts. Mutations in MYH have been observed in human colorectal tumors and lung cancer cell lines.
TRUSTED_SUSTAINABILITY

Specifications

Antigen MYH (33-51)
Applications Immunofluorescence, Immunohistochemistry (Paraffin)
Classification Polyclonal
Conjugate Unconjugated
Formulation Undiluted serum.
Host Species Rabbit
Immunogen a synthetic peptide (QEGRQKHAKNNSQAKPSAC) corresponding to amino acids 33-51 of human MYH
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Test Specificity Recognizes the MYH protein and several of its approximately 10 isoforms in PC12, Jurkat, and HeLa cells.
Target Species Human, Rat
Content And Storage −20°C
Form Undiluted
Isotype IgG
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For Research Use Only

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