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N-Cadherin Mouse, Unlabeled, Clone: 32, BD
Mouse Monoclonal Antibody
Supplier: BD Biosciences 610921
Description
Cadherins are a family of Ca2+;-dependent intercellular adhesion molecules that play a central role in controlling morphogenetic movements during development. Their function is regulated by association with the actin cytoskeleton by a complex of cytoplasmic proteins called the catenins (α, β, γ). Members of the cadherin family include P-cadherin, E-cadherin (uvomorulin), N-cadherin (neural cadherin), R-cadherin, cadherin 5, L-CAM, and EP-cadherin. N-cadherin mRNA is found at elevated levels in brain and heart and at a much lower level in liver. Mechanisms such as mRNA expression, cytokine modulation, and protease-mediated turnover modulate N-cadherin protein levels during development. In addition, N-cadherin function is indirectly regulated by endogenous kinases and phosphatases. Tyrosine phosphorylation of β-catenin complexed with N-cadherin results in dissociation of N-cadherin from actin. However, N-cadherin also interacts with a PTP1B-like phosphatase that dephosphorylates β-catenin and promotes N-cadherin/actin association. Thus, N-cadherin is an integral adhesion molecule whose function is regulated by protein-protein interactions and phosphorylation/dephosphorylation events.
Immunofluorescence, Western Blotting
Specifications
N-Cadherin | |
Monoclonal | |
250μg/mL | |
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide. | |
Mouse N-Cadherin aa. 802-819 | |
150 μg | |
Cell Biology | |
Chicken, Human, Mouse, Rat | |
IgG1 |
Western Blot | |
32 | |
Unconjugated | |
Mouse | |
Affinity Purified | |
RUO | |
Primary | |
Store undiluted at -20°C. |
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For Research Use Only.