Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More

NLRP3 Rat anti-Human, Mouse, Clone: 768319, Invitrogen™

Rat Monoclonal Antibody

Manufacturer:  Invitrogen MA523919

Catalog No. PIMA523919

Add to cart



In direct ELISAs, 100% cross-reactivity with recombit human NLRP3/NALP3 is observed. Reconstitute in sterile PBS to a final concentration of 0.5 mg/mL.

This gene encodes a pyrin-like protein containing a pyrin domain, a nucleotide-binding site domain, and a leucine-rich repeat motif. This protein interacts with the apoptosis-associated speck-like protein PYCARD/ASC, which contains a caspase recruitment domain, and is a member of the NALP3 inflammasome complex. This complex functions as an upstream activator of NF-kappaB signaling, and it plays a role in the regulation of inflammation, the immune response, and apoptosis. Mutations in this gene are associated with familial cold autoinflammatory syndrome syndrome, and neonatal-onset multisystem inflammatory disease . Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. Alternative 5 ft. UTR structures are suggested by available data; however, insufficient evidence is available to determine if all of the represented 5 ft. UTR splice patterns are biologically valid.


0.5 mg/mL
PBS with 5% trehalose and No Preservative
Q96P20, Q8R4B8
AGTAVPRL, AII, AVP, C1orf7, CIAS1, CLR1.1, FCAS, FCU, MWS, NALP3, PYPAF1, NACHT domain-, leucine-rich repeat-, and PYD-containing protein 3, NACHT, LRR and PYD containing protein 3, NACHT, LRR and PYD domains-containing protein 3, PYRIN-containing APAF1-like protein 1, caterpiller protein 1.1, cold autoinflammatory syndrome 1 protein, cryopyrin, nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 3
100 μg
-20° C, Avoid Freeze/Thaw Cycles
114548, 216799
Flow Cytometry, Immunocytochemistry, Immunofluorescence, Western Blot
E. coli-derived recombit mouse NLRP3/NALP3 Met1-Arg153
Protein A/G
Human, Mouse
Provide Content Correction

We continue to work to improve your shopping experience and your feedback regarding this content is very important to us. Please use the form below to provide feedback related to the content on this product.

Product Title

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.

Cancel Submit