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NLRP3 Rat anti-Human, Mouse, Clone: 768319, Invitrogen™

Rat Monoclonal Antibody

Manufacturer:  Invitrogen MA523919

Catalog No. PIMA523919


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Description

Description

In direct ELISAs, 100% cross-reactivity with recombit human NLRP3/NALP3 is observed. Reconstitute in sterile PBS to a final concentration of 0.5 mg/mL.

This gene encodes a pyrin-like protein containing a pyrin domain, a nucleotide-binding site domain, and a leucine-rich repeat motif. This protein interacts with the apoptosis-associated speck-like protein PYCARD/ASC, which contains a caspase recruitment domain, and is a member of the NALP3 inflammasome complex. This complex functions as an upstream activator of NF-kappaB signaling, and it plays a role in the regulation of inflammation, the immune response, and apoptosis. Mutations in this gene are associated with familial cold autoinflammatory syndrome syndrome, and neonatal-onset multisystem inflammatory disease . Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. Alternative 5 ft. UTR structures are suggested by available data; however, insufficient evidence is available to determine if all of the represented 5 ft. UTR splice patterns are biologically valid.
Specifications

Specifications

NLRP3
Monoclonal
0.5 mg/mL
PBS with 5% trehalose and No Preservative
Q96P20, Q8R4B8
AGTAVPRL, AII, AVP, C1orf7, CIAS1, CLR1.1, FCAS, FCU, MWS, NALP3, PYPAF1, NACHT domain-, leucine-rich repeat-, and PYD-containing protein 3, NACHT, LRR and PYD containing protein 3, NACHT, LRR and PYD domains-containing protein 3, PYRIN-containing APAF1-like protein 1, caterpiller protein 1.1, cold autoinflammatory syndrome 1 protein, cryopyrin, nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 3
Rat
IgG2A
100 μg
-20° C, Avoid Freeze/Thaw Cycles
Primary
114548, 216799
Flow Cytometry, Immunocytochemistry, Immunofluorescence, Western Blot
768319
Unconjugated
NLRP3
Lyophilized
NLRP3
E. coli-derived recombit mouse NLRP3/NALP3 Met1-Arg153
Protein A/G
RUO
Antibody
Monoclonal
Human, Mouse
Documents
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