natriuretic peptide receptor B/guanylate cyclase B (atrionatriuretic peptide receptor B), Mouse, Clone: 1E4, Abnova™

Catalog No.	Quantity
89-000-847	100 μg

Catalog No. 89-000-847 Supplier Abnova Corporation Supplier No. H00004882M02

Description

Mouse monoclonal antibody raised against a partial recombinant NPR2.

This gene encodes natriuretic peptide receptor B, one of two integral membrane receptors for natriuretic peptides. Both NPR1 and NPR2 contain five functional domains: an extracellular ligand-binding domain, a single membrane-spanning region, and intracellularly a protein kinase homology domain, a helical hinge region involved in oligomerization, and a carboxyl-terminal guanylyl cyclase catalytic domain. The protein is the primary receptor for C-type natriuretic peptide (CNP), which upon ligand binding exhibits greatly increased guanylyl cyclase activity. Mutations in this gene are the cause of acromesomelic dysplasia Maroteaux type. [provided by RefSeq

Sequence: AKNDHYRTLVRTGPSAPKLGEFVVTLHGHFNWTARAALLYLDARTDDRPHYFTIEGVFEALQGSNLSVQHQVYAREPGGPEQATHFIRANGRIVYICGPL

Specifications

• Antigen: natriuretic peptide receptor B/guanylate cyclase B (atrionatriuretic peptide receptor B)
• Applications: ELISA, Immunohistochemistry (PFA fixed), Western Blot
• Classification: Monoclonal
• Clone: 1E4
• Conjugate: Unconjugated
• Description: Mouse monoclonal antibody raised against a partial recombinant NPR2.
• Formulation: PBS with no preservative; pH 7.4
• Gene: NPR2
• Gene Accession No.: NM_003995.3
• Gene Alias: AMDM/ANPRB/GUC2B/GUCY2B/NPRB/NPRBi
• Gene Symbols: NPR2
• Host Species: Mouse
• Immunogen: NPR2 (NP_003986.2, 131 a.a. ∼ 230 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
• Purification Method: Affinity Purified
• Quantity: 100 μg
• Regulatory Status: RUO
• Research Discipline: Kinases
• Whole Molecule: Yes
• Primary or Secondary: Primary
• Gene ID (Entrez): 4882
• Target Species: Human
• Content And Storage: Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
• Product Type: Antibody
• Isotype: IgG2b κ