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Oct3/4 Mouse, Unlabeled, Clone: 40/OCT-3, BD

Catalog No. p-3967715 Shop All BD Biosciences Products
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BDB611202 50 μg
BDB611203 150 μg
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Catalog No. BDB611202 Supplier BD Biosciences Supplier No. 611202
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Description

Mouse Monoclonal Antibody

Development of a multicellular organism from a single fertilized cell is regulated by the coordinated activity of DNA transcription factors. Oct3/4, a member of the POU family of transcription factors, functions in pluripotent cells of early embryonic stem cell (ES) lines and embryonal carcinomas (EC). Other members of the POU family include Oct1, Oct2, Pit-1, and unc-86. The POU domain, a 150-amino acid region that determines binding specificity, is conserved among these proteins and consists of 3 subdomains: POU-specific A and B
subdomains and a homeobox-like subdomain. Oct3/4 is expressed in undifferentiated cells, but is lost as cells are induced to differentiate. Oct3/4 is not expressed in adult tissues. The interaction of Oct3/4 with SOX2, another embryonic transcription factor, produces an active complex that regulates expression of genes such as Nanog, UTF1, and FGF4. Although Oct3/4 is specifically phosphorylated on serine residues, this modification is not required for DNA binding, but may affect its transactivation potential. Thus, Oct3/4 is a transcription factor that plays an important role in determining early steps of embryogenesis and differentiation.

Host Species: Mouse
Clone: 40
Isotype: IgG1 κ
Species Reactivity: Human
Immunogen: Mouse Oct3 aa. 252-372 Recombinant Protein
Formula Weight [Chemical]: 46kDa

Western Blotting

TRUSTED_SUSTAINABILITY

Specifications

Antigen OCT3/4
Applications In vitro Assay, Western Blot
Classification Monoclonal
Clone 40/OCT-3
Concentration 250μg/mL
Conjugate Unconjugated
Description Oct3, OTF3, Oct4, OTF4, POU5F1
Formulation Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Host Species Mouse
Immunogen Mouse Oct3 aa. 252-372 Recombinant Protein
Purification Method Affinity Purified
Quantity 50 μg
Regulatory Status RUO
Research Discipline Cell Biology
Primary or Secondary Primary
Target Species Human, Mouse
Content And Storage Store undiluted at -20°C.
Isotype IgG1 κ
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For Research Use Only.

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