Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
  1. Home
  2. Products
  3. Antibodies
  4. Primary Antibodies
  5. All Primary Antibodies
  6. BDB560313

p38 MAPK (pT180/pY182) Mouse, Pacific Blue, Clone: 36/P38 (PT180/PY182), BD

Catalog No. BDB560313 Shop All BD Biosciences Products
Change view
Click to view available options
Quantity:
50 Tests
1 product options available for selection
Product selection table with 1 available options. Use arrow keys to navigate and Enter or Space to select.
Catalog No. Quantity
BDB560313 50 Tests
Use arrow keys to navigate between rows. Press Enter or Space to select a product option. 1 options available.
1 options
Catalog No. BDB560313 Supplier BD Biosciences Supplier No. 560313
Only null left
Add to Cart
Add to Cart

Description

Mouse Monoclonal Antibody

Activation of the immune and inflammatory responses often involves the recognition of bacterial endotoxin (lipopolysaccharide or LPS). Binding of LPS by monocytes results in the production and release of proinflammatory cytokines, such as IL-1 and TNF. LPS-induced signaling cascades involve members of the Ser/Thr protein kinase family known as the Mitogen Activated Protein Kinases (MAPKs). MAPK signal transduction pathways mediate the effects of various extracellular stimuli on biological processes such as proliferation, differentiation, and death. The p38 MAPKs include p38α (MAPK14), β (MAPK11), γ (MAPK12), and δ (MAPK13). These Ser/Thr kinases are activated by
dual phosphorylation on threonine (T) and tyrosine (Y) within the motif Thr-Gly-Tyr located in kinase subdomain VIII. Activation of p38 MAPK is mediated specifically by the MAP Kinase Kinases, MKK3, MKK4, and MKK6. This leads to the activation of multiple transcription factors (NF-κB, ATF-2, Elk-1, and CHOP) that induce expression of many different genes, including proinflammatory cytokine genes. Thus, p38 MAPKs are central kinases in multiple signal transduction pathways. The 36/p38 (pT180/pY182) monoclonal antibody recognizes the conserved dual phosphorylated site pT180/pY182 of p38α, β, γ, and δ.

Host Species: Mouse
Clone: 36
Isotype: IgG1 κ
Species Reactivity: Human
Immunogen: Phosphorylated Human p38 MAPK (pT180/pY182) Peptide

Intracellular Staining

TRUSTED_SUSTAINABILITY

Specifications

Antigen p38 MAPK (pT180/pY182)
Applications Flow Cytometry
Classification Monoclonal
Clone 36/P38 (PT180/PY182)
Conjugate Pacific Blue
Description MAPK14; p38 MAP kinase; p38 MAPK; RK; CSBP2
Formulation Aqueous buffered solution containing BSA, protein stabilizer, and ≤0.09% sodium azide.
Host Species Mouse
Immunogen Phosphorylated Human p38 MAPK (pT180/pY182) Peptide
Purification Method Affinity Purified
Quantity 50 Tests
Regulatory Status RUO
Research Discipline Cell Biology
Primary or Secondary Primary
Target Species Human, Mouse, Rat
Content And Storage Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Isotype IgG1 κ
Show More Show Less
Product Title
Select an issue

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.