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p53 (acK382) Mouse anti-Human, Alexa Fluor 647, Clone: L82-51, BD

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Catalog No. BDB560231 Supplier BD Biosciences Supplier No. 560231
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Description

Mouse Monoclonal Antibody

The p53 protein is critical to regulation of normal cell growth and proliferation and is a suppressor of tumor cell proliferation. Inactivation of p53 by a number of mechanisms, such as missense mutations or interaction with oncogenic viral or cellular proteins, can result in tumor progression. Mutations and/or allelic loss of the p53 gene are associated with a wide variety of human tumors. Known to have a role in transcriptional regulation, p53 suppresses various promoters containing TATA elements in an apparently sequence-independent fashion. p53 also binds to DNA in a sequence-specific manner via recognition of a 20-bp consensus-binding site. This interaction stimulates the expression of genes downstream of the p53 binding site. A number of genes that contain p53-binding sites have been identified, including MDM2, GADD45, and muscle creatine kinase. Post-translational acetylation of p53 enhances its DNA-binding activity. There are multiple factors that affect p53 acetylation, thereby modulating cellular proliferation and apoptosis.
The L82-51 monoclonal antibody recognizes acetylated lysine 382 (acK382) in the C-terminal region of p53.

Host Species: Mouse
Clone: L82-51
Isotype: IgG1 κ
Species Reactivity: Human
Immunogen: Human p53 acetylated Peptide

Intracellular Staining

TRUSTED_SUSTAINABILITY

Specifications

Antigen p53 (acK382)
Applications Flow Cytometry
Classification Monoclonal
Clone L82-51
Conjugate Alexa Fluor 647
Description TP53 (acK382)
Formulation Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
Host Species Mouse
Immunogen Human p53 acetylated Peptide
Purification Method Affinity Purified
Quantity 50 Tests
Regulatory Status RUO
Research Discipline Cell Biology
Primary or Secondary Primary
Target Species Human
Content And Storage Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Isotype IgG1 κ
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