PAC-1 Mouse anti-Human, Unlabeled, Clone: PAC-1, BD

Mouse Monoclonal Antibody

Supplier:  BD Biosciences 340535

Catalog No. BDB340535

Description

PAC-1 recognizes an epitope on the glycoprotein IIb/IIIa (gpIIb/IIIa, aIIbb3) complex of activated platelets at or near the platelet fibrinogen receptor. The gpIIb/IIIa complex is a member of a family of heterodimeric adhesive protein receptors found on a variety of cell types that have been named the integrin or the cytoadhesion family.The gpIIb/IIIa complex is located on the surface membrane of resting platelets. Platelet activation induces a calcium-dependent conformational change in gpIIb/IIIa that exposes a ligand binding site. Four adhesive macromolecules are capable of interacting with the activated form of gpIIb/IIIa: fibrinogen, von Willebrand factor (vWf), fibronectin, and vitronectin. The binding of fibrinogen to the gpIIb/IIIa receptor is required for platelet aggregation. PAC-1 binds only to activated platelets and appears to be specific for this recognition site within gpIIb/IIIa. Approximately 45,000 to 50,000 gpIIb/IIIa receptors appear on the platelet surface upon activation. PAC-1 inhibits fibrinogen- mediated platelet aggregation.

Flow Cytometry, Immunohistochemistry

Specifications

• Antigen: PAC-1
• Classification: Monoclonal
• Concentration: 1mg/mL
• Formulation: Phosphate buffered saline with 0.01% sodium azide.
• Immunogen: Human platelets
• Quantity: 200 μg
• Research Discipline: Cell Biology
• Target Species: Human
• Isotype: IgM κ

• Applications: Flow Cytometry
• Clone: PAC-1
• Conjugate: Unconjugated
• Host Species: Mouse
• Purification Method: Affinity Purified
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Content And Storage: Store vials at 2-8°C. Conjugated forms should not be frozen and should be protected from prolonged exposure to light. Each reagent is stable for the period shown on the bottle label when stored as directed.

Safety and Handling

WARNING: Reproductive Harm - www.P65Warnings.ca.gov

For Research Use Only.