Parkin Rabbit anti-Human, Polyclonal, Invitrogen™
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA138412
Heat-mediated antigen retrieval is recommended prior to staining, using a 10mM citrate buffer, pH 6.0, for 10 minutes followed by cooling at room temperature for 20 min. Following antigen retrieval, incubate samples with primary antibody for 30 min at room temperature. A suggested positive control is Alzheimer′s brain tissue.Parkin has been mapped to chromosome 6 and encodes a protein of 465 amino acids with similarity to ubiquitin at the amino terminus and a RING-finger motif at the carboxyl terminus. Parkinson’s disease is the second most common neurodegenerative disease following Alzheimer’s. The characteristic movement disorder results from dysfunction and neuron loss in the substantia nigra. Deletions in parkin, have been associated with autosomal-recessive juvenile parkinsonism.
|PBS with 1% BSA and <0.1% sodium azide; pH 7.6|
|AR-JP, LPRS2, PDJ, PRKN, E3 ubiquitin-protein ligase parkin, Parkinson disease autosomal recessive, juvenile 2, parkin, parkinson juvenile disease protein 2|
|Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin)|
|Synthetic peptide derived from N-terminus of human parkin protein.|
|Antigen affinity chromatography|
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