Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More

PHD3 Mouse anti-Human, Clone: 3C5, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA522900

Catalog No. PIMA522900


Add to cart

Description

Description

Peptide Sequence: EMPLGHIMRL DLEKIALEYI VPCLHEVGFC YLDNFLGEVV GDCVLERVKQ LHCTGALRDG QLAGPRAGVS KRHLRGDQIT WIGGNEEGCE AISFLLSLID

HIF prolyl hydroxylase 3 is a prolyl hydroxylase that modifies HIF-alpha. Classic prolyl hydroxylases are found in the endoplasmic reticulum and modify collagen, whereas HIF is an intracellular protein and the HPH sites do not resemble those modifying collagen. HIF is a transcriptional complex that plays a critical role in oxygen homeostasis. HPH is an essential component of the pathway through which cells sense oxygen. In the presence of oxygen, HPHs convert specific prolyl residues in HIF-alpha to hydroxyproline, leading to HIF-alpha destruction. Low oxygen levels, sensed at the cellular level, cause the HIF conversion to be reduced so that HIF is stable and there is increased angiogenesis. HIF prolyl hydroxylase 1, specifically, catalyzes the posttranslational formation of 4-hydroxyproline in HIF alpha proteins. It hydroxylates HIF-1 alpha at Pro(564) and HIF-2 alpha. It targets HIF through the hydroxylation for proteasomal degradation via the von Hippel-Lindau ubiquitylation complex. It may also play a role in cell growth regulation in muscle cells and in apoptosis in neuronal tissues, promoting cell death through a caspase-dependent mechanism.
Specifications

Specifications

PHD3
Monoclonal
0.2-1.0 mg/mL
PBS with no preservative; pH 7.4
Q9H6Z9
HIFPH3, PHD3, HIF prolyl hydroxylase 3, HIF-PH3, HIF-prolyl hydroxylase 3, HPH-1, HPH-3, egl nine homolog 3, egl nine-like protein 3 isoform, hypoxia-inducible factor prolyl hydroxylase 3, prolyl hydroxylase domain-containing protein 3
Mouse
IgG2a, kappa
100 μg
-20° C, Avoid Freeze/Thaw Cycles
Primary
112399
ELISA
3C5
Unconjugated
EGLN3
Liquid
EGLN3
EGLN3 (AAH10992.2, 94 a.a. ∽ 193 a.a) partial recombit protein with GST tag. MW of the GST tag alone is 26 KDa.
Affinity chromatography
RUO
Antibody
Monoclonal
Human
Documents
Provide Content Correction

We continue to work to improve your shopping experience and your feedback regarding this content is very important to us. Please use the form below to provide feedback related to the content on this product.

Product Title

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.

Cancel Submit