Phospho-Tau (Ser202, Thr205) Mouse anti-Human, Clone: AT8, Invitrogen™
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MN1020
MN1020 targets PHF-tau (Ser202/Thr205)a in ELISA, IF, IHC(P), and WB applications and shows reactivity with Human samples. The MN1020 immunogen is partially purified human PHF-Tau. MN1020 detects PHF-tau (Ser202/Thr205)a which has a predicted molecular weight of approximately 79 kDa. This product is a Low Endotoxin formulation.Tau is a neuronal microtubule-associated protein found predomitly on axons. The function of Tau is to promote tubulin polymerization and stabilize microtubules. The C-terminus binds axonal microtubules while the N- terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton while the longer isoforms may preferentially play a role in its stabilization. In its hyper-phosphorylated form, Tau is the major component of paired helical filaments (PHF), the building block of neurofibrillary lesions in Alzheimer′s diseases (AD) brain. Hyper-phosphorylation impairs the microtubule binding function of Tau, resulting in the destabilization of microtubules in AD brains, ultimately leading to the degeneration of the affected neurons. Numerous serine/threonine kinases phosphorylate Tau, including GSK-3beta, protein kinase A (PKA), cyclindependent kinase 5 (cdk5) and casein kinase II. Hyper-phosphorylated Tau is found in neurofibrillary lesions in a range and other central nervous system disorders such as Pick′s disease, frontotemporal dementia, cortico-basal degeneration and progressive supranuclear palsy.
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|Phospho-Tau (Ser202, Thr205)|
|PBS with no preservative|
|G protein beta1/gamma2 subunit-interacting factor 1; PHF-tau; neurofibrillary tangle protein; paired helical filament-tau|
|-20° C, Avoid Freeze/Thaw Cycles|
|ELISA, Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot|
|Partially purified human PHF-Tau|
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