Invitrogen™ Phospho-ZAP70/Syk (Tyr319, Tyr352) Monoclonal Antibody (R.658.6)

Catalog No.	Quantity
PIMA515095	100 μL

Catalog No. PIMA515095 Supplier Invitrogen™ Supplier No. MA515095

Description

Rabbit Monoclonal Antibody

It is not recommended to aliquot this antibody.

ZAP-70 is a cytosolic protein tyrosine kinase that is a member of the Syk family of proteins. ZAP-70 is expressed exclusively in T-cells and natural killer cells and is required for T-cell receptor activation. Upon T cell antigen receptor (TCR) engagement, ZAP70 is phosphorylated on tyrosines 292, 315 and 319 in the interdomain B, located between the SH2 and kinase domains. Phosphorylation of both tyrosines 315 (a Vav binding site) and 319 (a Lck binding site) enhances ZAP70 function in mediating lymphocyte signaling, while tyrosine 292 terminates the transient activation of ZAP70 and attentuates lymphocyte signaling.

Specifications

• Antigen: Phospho-ZAP70/Syk (Tyr319, Tyr352)
• Applications: Western Blot
• Classification: Monoclonal
• Clone: R.658.6
• Conjugate: Unconjugated
• Formulation: 0.01M HEPES with 100μg/mL BSA, 50% glycerol, 0.15M NaCl and <0.02% sodium azide; pH 7.5
• Gene: ZAP70
• Gene Accession No.: P43403, P43404
• Gene Alias: 70 kDa zeta-associated protein; 70 kDa zeta-chain associated protein; ADMIO2; EC 2.7.10.2; FLJ17670; FLJ17679; I79_004087; IMD48; kinase ZAP70; mrtle; mur; Selective T cell defect; Srk; STCD; STD; syk-related protein tyrosine kinase; syk-related tyrosine kinase; Tyrosine-protein kinase ZAP-70; Tyrosine-protein kinase ZAP-70;TZK; TZK; ZA70; Zap70; ZAP-70; Zeta chain associated protein kinase 70kDa; zeta chain of T cell receptor associated protein kinase; zeta chain of T cell receptor associated protein kinase 70; zeta chain of T cell receptor associated protein kinase 70kDa; zeta-chain (TCR) associated protein kinase; zeta-chain (TCR) associated protein kinase 70; zeta-chain (TCR) associated protein kinase 70kDa; zeta-chain associated protein kinase 70kDa; zeta-chain associated protein kinase, 70kD
• Gene Symbols: LOC100739325, LOC100767740, ZAP70
• Host Species: Rabbit
• Immunogen: Synthetic phosphopeptide corresponding to residues surrounding pTyr319 of human Zap-70.
• Purification Method: Affinity chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 100147296, 100271860, 100739325, 100767740, 22637, 301348, 420086, 504509, 7535
• Target Species: Human, Mouse, Rat, Canine, Monkey, Bovine, Hamster, Pig, Horse, Chicken
• Content And Storage: -20°C
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG