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Phospholipase Cβ1 Mouse, Unlabeled, Clone: 16, BD

Mouse Monoclonal Antibody

Manufacturer:  BD Biosciences 610924

Catalog No. BDB610924

This item has been discontinued by the manufacturer and is no longer available. Please call customer service for assistance: 1-800-766-7000.


Description

Description

Phospholipase C (PLC) hydrolyzes inositol phospholipids into diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). The former causes release of Ca2+ from intracellular stores, while the latter is an activator of PKC. At least three isozymes are known: PLCβ, PLCγ, and PLCδ. They recognize phosphatidylinositol (PI), phosphatidylinositol 4-phosphate (PIP2), and phospatidylinositol 4,5 bisphosphate (PIP2) and carry out the Ca2+-dependent hydrolysis of these inositol phospholipids. All three classes contain two highly conserved regions, designated “X” and “Y”, whose structural integrity is essential for a functional catalytic core. The PLCβ subfamily has been reported to contain at least four members: β1, β2, β3 and β4. PLCβ1 has been reported to have been identified and cloned from brain tissue where the PLCβ1 gene encodes for two different mRNAs. The resulting protein products, PLCβ1a (121 aa) and PLCβ1b (1173 aa) differ only at their C-termini. Although PLCγ activity is induced by receptor tyrosine kinase phosphorylation, PLCβ is regulated by G protein α subunits or βγ subunits. In particular, Gαq has been reported to activate PLCβ1.

Immunofluorescence, Western Blotting

Specifications

Specifications

Phospholipase Cβ1
16
Unconjugated
Murine
IgG1
RUO
Primary
Human, Murine, Rat
Immunofluorescence, Western Blot
250μg/mL
Affinity Purified
Rat Phospholipase Cβ1 aa. 4-159
50μg
Cell Biology
Monoclonal
SDS
Documents
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