KV1.1 (KCNA1) Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA112652
A suggested positive control for this product is rat brain lysate.K+ channels from the Kv1 subfamily contain four alpha-subunits and the combinations (from Kv1.1-1.6) determine susceptibility to dendrotoxin (DTX) homologue. Kv1.1, a Shaker-like voltage-gated potassium channel, is strongly expressed in a variety of neurons in adult rodents, in which it appears to be involved in regulating neuronal excitability. Here we show that Kv1.1 is also expressed during embryonic development in the mouse, exhibiting two transient peaks of expression around embryonic day 9.5 (E9.5) and E14.5. Potassium channels play a critical role in limiting neuronal excitability. Mutations in certain voltage-gated potassium channels have been associated with hyperexcitable phenotypes in both humans and animals. However, only recently have mutations in potassium channel genes (i.e. KCNQ2 and KCNQ3) been discovered in a human epilepsy, benign familial neonatal convulsions.
|Synthetic peptide, conjugated to KLH, corresponding to the rat Kv1.1 potassium channel.|
|Ammonium sulfate precipitation|
|Human, Mouse, Rat|
|PBS with 0.08% sodium azide|
|Q09470, P16388, P10499|
|Kcna, Kcpvd, Kv1.1|
|-20° C, Avoid Freeze/Thaw Cycles|
|16485, 24520, 3736|
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