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KV1.1 (KCNA1) Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA112652

Catalog No. 01-674-807


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Description

Description

A suggested positive control for this product is rat brain lysate.

K+ channels from the Kv1 subfamily contain four alpha-subunits and the combinations (from Kv1.1-1.6) determine susceptibility to dendrotoxin (DTX) homologue. Kv1.1, a Shaker-like voltage-gated potassium channel, is strongly expressed in a variety of neurons in adult rodents, in which it appears to be involved in regulating neuronal excitability. Here we show that Kv1.1 is also expressed during embryonic development in the mouse, exhibiting two transient peaks of expression around embryonic day 9.5 (E9.5) and E14.5. Potassium channels play a critical role in limiting neuronal excitability. Mutations in certain voltage-gated potassium channels have been associated with hyperexcitable phenotypes in both humans and animals. However, only recently have mutations in potassium channel genes (i.e. KCNQ2 and KCNQ3) been discovered in a human epilepsy, benign familial neonatal convulsions.
Specifications

Specifications

KV1.1 (KCNA1)
Polyclonal
Unconjugated
KCNA1
Liquid
KCNA1
Synthetic peptide, conjugated to KLH, corresponding to the rat Kv1.1 potassium channel.
Ammonium sulfate precipitation
RUO
Antibody
Polyclonal
Human, Mouse, Rat
Western Blot
1 mg/mL
PBS with 0.08% sodium azide
Q09470, P16388, P10499
Kcna, Kcpvd, Kv1.1
Rabbit
IgG
100 μg
-20° C, Avoid Freeze/Thaw Cycles
Primary
16485, 24520, 3736
Documents
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