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PRAS40 Mouse anti-Human, Clone: 73P21, Invitrogen™ Non-distribution product as customer accommodation. Available on GSA/VA Contract for Federal Government customers only.

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen AHO1031

Catalog No. AHO1031


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Description

Description

The Akt signaling pathway contributes to the regulation of apoptosis after a variety of cell death signals. AKT1S1, also known as PRAS40, is a proline-rich substrate of the kinase AKT1 and is thought to play a role in neuroprotection mediated by nerve growth factor (NGF) after transient focal cerebral ischemia. AKT1S1 is also a substrate and potential regulator of mammalian target of rapamycin (mTOR), a serine/threonine kinase that regulates cell growth and cell cycle, and a negative regulator of autophagy. Treatment with the insulin-like growth factor-1 (IGF1) can indusce the phosphorylation of AKT1S1 via the PI3K/AKT signaling pathway in PC12 cells.

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Specifications

Specifications

PRAS40
Monoclonal
Unconjugated
AKT1S1
Liquid
AKT1S1
Recombit full length human PRAS40 expressed in E. coli.
Purified
RUO
Antibody
Monoclonal
Human
Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
73P21
PBS with 1% BSA and 0.1% sodium azide
Q96B36
40 kDa proline-rich AKT substrate, OTTHUMP00000196756, OTTHUMP00000196760, proline-rich AKT1 substrate 1, proline-rich Akt substrate, 40 kDa
Mouse
IgG1, kappa
100 μg
-20°C
Primary
84335
SDS
Documents
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