PRAS40 Mouse anti-Human, Clone: 73P21, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen AHO1031
DescriptionThe Akt signaling pathway contributes to the regulation of apoptosis after a variety of cell death signals. AKT1S1, also known as PRAS40, is a proline-rich substrate of the kinase AKT1 and is thought to play a role in neuroprotection mediated by nerve growth factor (NGF) after transient focal cerebral ischemia. AKT1S1 is also a substrate and potential regulator of mammalian target of rapamycin (mTOR), a serine/threonine kinase that regulates cell growth and cell cycle, and a negative regulator of autophagy. Treatment with the insulin-like growth factor-1 (IGF1) can indusce the phosphorylation of AKT1S1 via the PI3K/AKT signaling pathway in PC12 cells.
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|Recombit full length human PRAS40 expressed in E. coli.|
|Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot|
|PBS with 1% BSA and 0.1% sodium azide|
|40 kDa proline-rich AKT substrate, OTTHUMP00000196756, OTTHUMP00000196760, proline-rich AKT1 substrate 1, proline-rich Akt substrate, 40 kDa|
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