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proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7), Rabbit, Purified MaxPab™ Polyclonal Antibody, Abnova™
Rabbit polyclonal antibody raised against a full-length human PSMB8 protein.
Supplier: Abnova Corporation H00005696D01P
Description
The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 nonidentical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a nonlysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. This gene is located in the class II region of the MHC (major histocompatibility complex). Expression of this gene is induced by gamma interferon and this gene product replaces catalytic subunit 3 (proteasome beta 5 subunit) in the immunoproteasome. Proteolytic processing is required to generate a mature subunit. Two alternative transcripts encoding two isoforms have been identified; both isoforms are processed to yield the same mature subunit. [provided by RefSeq
Sequence: MLIGTPTPRDTTPSSWLTSSLLVEAAPLDDTTLPTPVSSGCPGLEPTEFFQSLGGDGERNVQIEMAHGTTTLAFKFQHGVIAAVDSRASAGSYISALRVNKVIEINPYLLGTMSGCAADCQYWERLLAKECRLYYLRNGERISVSAASKLLSNMMCQYRGMGLSMGSMICGWDKKGPGLYYVDEHGTRLSGNMFSTGSGNTYAYGVMDSGYRPNLSPEEAYDLGRRAIAYATHRDSYSGGVVNMYHMKEDGWVKVESTDVSDLLHQYREANQSpecifications
proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7) | |
Polyclonal | |
Rabbit polyclonal antibody raised against a full-length human PSMB8 protein. | |
PSMB8 | |
D6S216/D6S216E/LMP7/MGC1491/PSMB5i/RING10/beta5i | |
Rabbit | |
Affinity Purified | |
RUO | |
Primary | |
Human, Mouse | |
Antibody |
Western Blot | |
Unconjugated | |
PBS with no preservative; pH 7.4 | |
NM_004159 | |
PSMB8 | |
PSMB8 (NP_004150.1, 1 a.a. ∼ 272 a.a) full-length human protein. | |
100 μg | |
Stem Cell Biology | |
5696 | |
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. | |
IgG |
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