Invitrogen™ RCAN2 Polyclonal Antibody

Catalog No.	Quantity
PIPA520695	100 μg

Catalog No. PIPA520695 Supplier Invitrogen™ Supplier No. PA520695

Description

Rabbit Polyclonal Antibody

A suggested positive control is NIH-3T3 cell lysate. PA5-20695 can be used with blocking peptide PEP-0810.

Regulator of calcineurin 2 (RCAN2), also known as ZAKI4 and DSCR1L1, is expressed as two isoforms differing at their N-terminus. The longer of the two (isoform 1) is expressed exclusively in the brain, while isoform 2 is ubiquitously expressed, with highest expression in brain, heart, and muscle. Both isoforms bind to the catalytic subunit of calcineurin, a Ca++-dependent protein phosphatase involved in several neuronal functions, though their C-terminal region and inhibit calcineurin's activity. Unlike isoform 1 of RCAN2, the expression of the second isoform is not induced by the thyroid hormone T3. RCAN2 is a member of a family of three endogenous calcineurin regulators that are located near the minimal supernumerary fragment of chromosome 21 in individuals with Down syndrome, suggesting that they play a role in this syndrome. Multiple isoforms of RCAN2 are known to exist.

Specifications

• Antigen: RCAN2
• Applications: Immunohistochemistry, Western Blot
• Classification: Polyclonal
• Concentration: 1 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 0.02% sodium azide
• Gene: Rcan2
• Gene Accession No.: Q14206, Q8CH27, Q9JHG2
• Gene Alias: calcineurin inhibitory protein ZAKI-4; Calcipressin-2; caskin-1-like; CSP2; Dcip2; Down syndrome candidate region 1-like 1; down syndrome candidate region 1-like protein 1; Down syndrome critical region gene 1-like 1; Down syndrome critical region gene 1-like 1 protein; Down syndrome critical region gene1-like 1; DSCR1L1; DSCR1L1 protein; LOW QUALITY PROTEIN: calcipressin-2; MCIP2; myocyte-enriched calcineurin interactin protein 2; myocyte-enriched calcineurin-interacting protein 2; Rcan2; RCN2; regulator of calcineurin 2; si:ch211-124g24.1; thyroid hormone-responsive (skin fibroblasts); thyroid hormone-responsive protein ZAKI-4; translation initiation factor IF-2; ZAKI4; ZAKI-4; zgc:85746
• Gene Symbols: Rcan2
• Host Species: Rabbit
• Immunogen: A 14 amino acid peptide near the center of human RCAN2.
• Purification Method: Antigen Affinity Chromatography
• Quantity: 100 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 10231, 140666, 53901
• Target Species: Human, Mouse, Rat
• Content And Storage: Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG