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RCAN2 Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA520695

Catalog No. PIPA520695


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Description

Description

A suggested positive control is NIH-3T3 cell lysate. PA5-20695 can be used with blocking peptide PEP-0810.

Regulator of calcineurin 2 (RCAN2), also known as ZAKI4 and DSCR1L1, is expressed as two isoforms differing at their N-terminus. The longer of the two (isoform 1) is expressed exclusively in the brain, while isoform 2 is ubiquitously expressed, with highest expression in brain, heart, and muscle. Both isoforms bind to the catalytic subunit of calcineurin, a Ca++-dependent protein phosphatase involved in several neuronal functions, though their C-terminal region and inhibit calcineurin’s activity. Unlike isoform 1 of RCAN2, the expression of the second isoform is not induced by the thyroid hormone T3. RCAN2 is a member of a family of three endogenous calcineurin regulators that are located near the minimal supernumerary fragment of chromosome 21 in individuals with Down syndrome, suggesting that they play a role in this syndrome. Multiple isoforms of RCAN2 are known to exist.
Specifications

Specifications

RCAN2
Polyclonal
Unconjugated
RCAN2
Liquid
RCAN2
A 14 amino acid peptide near the center of human RCAN2.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse, Rat
Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Western Blot
1 mg/mL
PBS with 0.02% sodium azide
Q14206, Q9JHG2, Q8CH27
Csp2, Dscr1l1, MCIP2, ZAKI-4; Down syndrome critical region gene 1-like 1; calcineurin inhibitory protein ZAKI-4; calcipressin-2; down syndrome candidate region 1-like protein 1; myocyte-enriched calcineurin interactin protein 2; myocyte-enriched calcineurin-interacting protein 2
Rabbit
IgG
100 μg
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Primary
10231, 140666, 53901
Documents
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