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RORγt Mouse anti-Human, PE, Clone: Q21-559, BD

Catalog No. BDB563081 Shop All BD Biosciences Products
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Catalog No. BDB563081 Supplier BD Biosciences Supplier No. 563081
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Mouse Monoclonal Antibody

The Q21-559 monoclonal antibody recognizes ROR gamma t (RORγt), an isoform of RORgamma (RORγ). RORγt is a DNA-binding transcription factor that is encoded by the RORC (RAR-related orphan receptor C) gene. It belongs to the ROR/RZR orphan nuclear receptor family. Two protein isoforms are produced from the RORC gene by alternative splicing: RORγγt is highly restricted to the thymus where it is expressed exclusively in immature CD4+CD8+ thymocytes and in peripheral Th17 and LTi cells. RORγt reportedly functions as an essential transcription factor for the development of secondary lymphoid tissues. It also plays an important regulatory role in thymopoiesis and effector T cell differentiation, especially for Th17 cells.

TRUSTED_SUSTAINABILITY

Specifications

Antigen RORγt
Applications Flow Cytometry
Classification Monoclonal
Clone Q21-559
Conjugate PE
Description RORgt; ROR gamma t; RORC; NR1F3; RORG; RZRG; TOR; RZR-GAMMA
Formulation Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
Host Species Mouse
Immunogen Human RORγt Recombinant Protein
Purification Method Affinity Purified
Quantity 50 Tests
Regulatory Status RUO
Primary or Secondary Primary
Target Species Human
Content And Storage Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Isotype IgG2b κ
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