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RUNX2 Rabbit anti-Chicken, Equine, Human, Mouse, Non-human primate, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA141519
PA1-41519 detects RUNX2 in chicken, chimpanzee, new world monkey, equine, human and mouse samples. This antibody is predicted to react with rat, pufferfish, zebrafish, and xenopus based on sequence homology.RUNX2, a nuclear protein, is a member of the RUNX family of transcription factors and has an Runt DNA-binding domain. It is essential for membranous and endochondral bone formation. It not only regulates osteoblastic differentiation and skeletal morphogenesis but also acts as a scaffold for nucleic acids and regulatory factors involved in skeletal gene expression. The protein can bind DNA both as a monomer and with more affinity, as a subunit of a heterodimeric complex. It plays a critical role in increasing TGFBR1 expression by osteoblasts and functions in cooperation with DLX5 or a related factor to activate osteoblast-specific gene expression. Mutations lead to disorders in bone development like cleidocranial dysplasia (CCD).
|Synthetic peptide corresponding to residues 264-279 of human RUNX2.|
|Chicken, Equine, Human, Mouse, Non-human primate|
|PBS with 0.05% BSA and 0.05% sodium azide|
|-20° C, Avoid Freeze/Thaw Cycles|
|100033890, 12393, 373919, 860|