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Stat5 (pY694) Mouse anti-Human, Unlabeled, Clone: 47, BD

Mouse Monoclonal Antibody

$319.00 - $545.00

Specifications

Antigen Stat5 (pY694)
Isotype IgG1, κ
Immunogen Phosphorylated Sheep Stat5 Peptide
Formulation Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Conjugate Unconjugated
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Products 2
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
BDB611964
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BD Biosciences
611964
50μg
Each for $319.00
Add to cart
 
BDB611965
View Documents
BD Biosciences
611965
150μg
Each for $545.00
Add to cart
 
Description

Description

The Stat proteins function both as cytoplasmic signal transducers and as activators of transcription. Seven mammalian STATs have been identified: Stat 1-4, Stat5a, 5b, and Stat6. The SH3 domain of Stat5 shows extensive homology with the SH2 domains of Stat1 and Stat2. This homology leads to speculation that it may have a broader physiological role than originally anticipated and has led to its classification as a member of the Stat family. Stat5 has been further characterized and shown to be encoded by two separate genes, Stat5a and Stat5b that share over 90% identity at the amino acid level. Further insight into the exact biological role of Stat5a and Stat5b was determined with the generation of Stat5a and Stat5b deficient mice. Stat5a was shown to be involved in lactogenesis and mammary development, while Stat5b was shown to be involved in growth hormone signaling and to play a role in liver gene expression. Both Stat5a and Stat5b share similarities, both are involved in IL-2 induced peripheral T cell proliferation. Stat5 (MGF) mRNA expression is highest in mammary gland tissue. Lower levels are found in ovary, thymus, spleen, kidney, lung, muscle, and the adrenal gland. The peptide hormone, prolactin, binds to the prolactin receptor (PRLR) to initiate the lactogenic response. There are at least three forms of PRLR; however, only the long form is able to activate the 92kDa Stat5 protein by inducing phosphorylation at Tyr694. Once phosphorylated, Stat5 becomes an essential transcription factor which binds to the β-casein gene promoter. Stat5 activity is tightly regulated throughout gestation, lactation, and post-lactation. Treatment of activated Stat5 with a protein tyrosine phosphatase results in the loss of DNA binding activity. The presence of an SH2 domain within Stat5 suggests that it may directly interact with protein tyrosine kinases (PTKs) such as JAK2.

Host Species: Mouse
Clone: 47
Isotype: IgG1, κ
Species Reactivity [for Features Main]: Human
Immunogen: Phosphorylated Sheep Stat5 Peptide

Intracellular Staining, Western Blotting

Specifications

Specifications

Stat5 (pY694)
Phosphorylated Sheep Stat5 Peptide
Unconjugated
Cell Biology
Mouse
Affinity Purified
Monoclonal
Store undiluted at -20°C.
IgG1, κ
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Primary
Western Blot
RUO
47
250μg/mL
SDS
Product Certifications

For Research Use Only.

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