STING Rabbit anti-Human, Mouse, Non-human primate, Rat, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA523381
DescriptionSTING is a 379 amino acid containing signaling protein that acts as an important component of innate immune signaling. This signaling protein is able to activate both NF-kappa-B and IRF3 transcription pathways to induce expression of type I interferon (IFN-alpha and IFN-beta) and exert a potent anti-viral state following expression. STING may have translocon function, the translocon possibly being able to influence the induction of type I interferons and is also involved in transduction of apoptotic signals via its association with the major histocompatibility complex class II (MHC-II) thus facilitating the detection of intracellular viral RNA species as well as B-form DNA and mediates death signaling via activation of the extracellular signal-regulated kinase (ERK) pathway. Generally seen in endoplasmic reticulum membrane, cell membrane and mitochondrion outer membrane, it is ubiquitously expressed in most of tissues.
|Synthetic peptide (310-360) of STING protein.|
|Human, Mouse, Non-human primate, Rat|
|Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot|
|PBS with 0.05% sodium azide|
|Q86WV6, Q3TBT3, F1M391|
|ERIS, MITA, MPYS, NET23, STING, N-terminal methionine-proline-tyrosine-serine plasma membrane tetraspanner, endoplasmic reticulum IFN stimulator, endoplasmic reticulum interferon stimulator, hMITA, hSTING, mediator of IRF3 activation, mitochondrial mediator of IRF3 activation, stimulator of interferon genes protein|
|Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|340061, 498840, 72512|
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