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STING Rabbit anti-Human, Mouse, Non-human primate, Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA523381

Catalog No. PIPA523381


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Description

Description

STING is a 379 amino acid containing signaling protein that acts as an important component of innate immune signaling. This signaling protein is able to activate both NF-kappa-B and IRF3 transcription pathways to induce expression of type I interferon (IFN-alpha and IFN-beta) and exert a potent anti-viral state following expression. STING may have translocon function, the translocon possibly being able to influence the induction of type I interferons and is also involved in transduction of apoptotic signals via its association with the major histocompatibility complex class II (MHC-II) thus facilitating the detection of intracellular viral RNA species as well as B-form DNA and mediates death signaling via activation of the extracellular signal-regulated kinase (ERK) pathway. Generally seen in endoplasmic reticulum membrane, cell membrane and mitochondrion outer membrane, it is ubiquitously expressed in most of tissues.
Specifications

Specifications

STING
Polyclonal
Unconjugated
TMEM173
Liquid
TMEM173
Synthetic peptide (310-360) of STING protein.
Affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse, Non-human primate, Rat
Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
1.0 mg/mL
PBS with 0.05% sodium azide
Q86WV6, Q3TBT3, F1M391
ERIS, MITA, MPYS, NET23, STING, N-terminal methionine-proline-tyrosine-serine plasma membrane tetraspanner, endoplasmic reticulum IFN stimulator, endoplasmic reticulum interferon stimulator, hMITA, hSTING, mediator of IRF3 activation, mitochondrial mediator of IRF3 activation, stimulator of interferon genes protein
Rabbit
IgG
100 μg
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Primary
340061, 498840, 72512
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