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  6. Syk w/control Mouse anti-Human, Unlabeled, Clone: 4D10, BD

Syk w/control Mouse anti-Human, Unlabeled, Clone: 4D10, BD

Catalog No. p-3972017 Shop All BD Biosciences Products
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Catalog No. Quantity
BDB551817 150 μg
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Catalog No. BDB551817 Supplier BD Biosciences Supplier No. 551817

Description

Mouse Monoclonal Antibody with Control

Syk is a member of the family of non-receptor type protein-tyrosine kinases and plays a crucial role in lymphocyte signaling and development. Syk is expressed in all haematopoietic cells and contributes to the signal transduction process by binding to a tyrosine-based activation motif (ITAM) of immune receptors, including Igα, TCRζ, CD3ε, FcεRIβ, and FceRIγ. Upon receptor activation, Syk binds to phosphorylated ITAMs via its two N-terminal SH2 domains thereby activating Syk and causing tyrosines in Syk to undergo auto-phosphorylation or phosphorylation. These phosphorylated sites can act as binding sites for other signaling molecules or help to regulate enzymatic activity. For example, in mast cells, Syk can activate downstream targets such as phospholipase Cγ1 and VAV. Studies in Syk-/- mast cells identified defects in both the ERK-MAP and JNK-MAP kinase pathways. Syk migrates as 72kDa in SDS/PAGE. (Predicted MW from SWISS-PROT is 72kDa; Accession number P43405).

Host Species: Mouse
Clone: 4D10
Isotype: IgG2a κ
Species Reactivity: Human
Immunogen: Human Syk peptide aa. 314-339

Western Blotting

TRUSTED_SUSTAINABILITY

Specifications

Antigen Syk w/control
Applications Western Blot
Classification Monoclonal
Clone 4D10
Conjugate Unconjugated
Formulation Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Host Species Mouse
Immunogen Human Syk peptide aa. 314-339
Purification Method Affinity Purified
Quantity 150 μg
Regulatory Status RUO
Research Discipline Cell Biology
Primary or Secondary Primary
Target Species Human
Content And Storage Store undiluted at -20°C.
Isotype IgG2a
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For Research Use Only.

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