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α-Synuclein (pY125) Mouse anti-Human, Unlabeled, Clone: I57-628, BD

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BDB558246 0.1 mg
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Catalog No. BDB558246 Supplier BD Biosciences Supplier No. 558246
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Description

Mouse Monoclonal Antibody

The 140-amino-acid α -Synuclein protein is identical to the non-amyloid- β component precursor (NACP), a presynaptic protein involved in amyloidogenesis in Alzheimer's disease (AD). This protein is expressed in brain, primarily in presynaptic nerve terminals. Although the exact function of the Synucleins has not been determined, they have been linked to the prominent neurodegenerative disorders AD and Parkinson's disease. The Tyrosine 125 (Y125) residue of α -Synuclein plays an important role in stress-induced dimerization of the protein and is phosphorylated by Pyk/RAFTK via the Src-family kinases Fyn and c-Src.

The I57-628 antibody recognizes α -Synuclein phosphorylated at Y125.

TRUSTED_SUSTAINABILITY

Specifications

Antigen α-Synuclein (pY125)
Applications Western Blot
Classification Monoclonal
Clone I57-628
Concentration 0.5mg/mL
Conjugate Unconjugated
Formulation Aqueous buffered solution containing ≤0.09% sodium azide.
Host Species Mouse
Immunogen Phosphorylated peptide corresponding to the region including the Tyrosine 125 residue of α-Synuclein
Purification Method Affinity Purified
Quantity 0.1 mg
Regulatory Status RUO
Research Discipline Cell Biology
Primary or Secondary Primary
Target Species Human
Content And Storage Store undiluted at 4°C
Isotype IgG2b κ
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For Research Use Only.

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