α-Synuclein (pY125) Mouse anti-Human, Unlabeled, Clone: I57-628, BD

Mouse Monoclonal Antibody

Supplier:  BD Biosciences 558246

Catalog No. BDB558246

Description

The 140-amino-acid α -Synuclein protein is identical to the non-amyloid- β component precursor (NACP), a presynaptic protein involved in amyloidogenesis in Alzheimer's disease (AD). This protein is expressed in brain, primarily in presynaptic nerve terminals. Although the exact function of the Synucleins has not been determined, they have been linked to the prominent neurodegenerative disorders AD and Parkinson's disease. The Tyrosine 125 (Y125) residue of α -Synuclein plays an important role in stress-induced dimerization of the protein and is phosphorylated by Pyk/RAFTK via the Src-family kinases Fyn and c-Src.

The I57-628 antibody recognizes α -Synuclein phosphorylated at Y125.

Specifications

• Antigen: α-Synuclein (pY125)
• Classification: Monoclonal
• Concentration: 0.5mg/mL
• Formulation: Aqueous buffered solution containing ≤0.09% sodium azide.
• Immunogen: Phosphorylated peptide corresponding to the region including the Tyrosine 125 residue of α-Synuclein
• Quantity: 0.1 mg
• Research Discipline: Cell Biology
• Target Species: Human
• Isotype: IgG2b κ

• Applications: Western Blot
• Clone: I57-628
• Conjugate: Unconjugated
• Host Species: Mouse
• Purification Method: Affinity Purified
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Content And Storage: Store undiluted at 4°C

For Research Use Only.