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γδ T Lymphocytes Rat anti-Pig, Unlabeled, Clone: MAC320, BD

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Description

Rat Monoclonal Antibody

The MAC320 antibody monoclonal antibody specifically binds to the 270- and 280-kDa isoforms of the SWC6 heterodimer expressed on Null T cells. These cells form a unique population of CD2-, surface Ig-, and thymus-dependent nylon wool-nonadherent peripheral blood lymphocytes found at high frequencies in young pigs. Null T cells are also CD4- and CD8-, and the majority of them express γδ T-cell receptors (TCR). In addition to peripheral blood, MAC320+ leukocytes (CD2- γδ T cells) are found in the thymus, especially in the medulla and in the marginal zone and red pulp of the spleen. They are rare in normal lymph nodes, tonsils, Peyer's patches, bone marrow, and skin. An additional population of MAC320- CD2+ γδ T cells is found in the blood and spleen. The MAC320 antibody does not react with pig erythrocytes, monocytes, or granulocytes, nor with cow, sheep, or human lymphocytes.

TRUSTED_SUSTAINABILITY

Specifications

Antigen γδ T Lymphocytes
Applications Flow Cytometry
Classification Monoclonal
Clone MAC320
Concentration 0.5mg/mL
Conjugate Unconjugated
Formulation Aqueous buffered solution containing ≤0.09% sodium azide.
Host Species Rat
Immunogen Null T cells purified from the blood of young pigs
Purification Method Affinity Purified
Quantity 0.1 mg
Regulatory Status RUO
Research Discipline Immunology
Primary or Secondary Primary
Target Species Pig
Content And Storage Store undiluted at 4°C
Isotype IgG2a κ
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For Research Use Only.

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