Invitrogen™ TCP-1 theta Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA521689

Catalog No. PIPA521689

Description

Recommended positive controls: 293T, A431, H1299, HeLa, HepG2, Molt-4, Raji, mouse brain. Predicted reactivity: Mouse (95%), Rat (94%), Zebrafish (82%), Xenopus laevis (87%), Chicken (91%), Rhesus Monkey (99%), Chimpanzee (99%), Bovine (96%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

TCP-1 theta is theta subunit of the CCT (chaperonin containing TCP1 complex) chaperonin molecule which is abundant in the eukaryotic cytosol and may be involved in the transport and assembly of the newly synthesized proteins. Molecular chaperones assist in the protein folding upon ATP hydrolysis and TCP-1 theta may play a role in the assembly of the BBsome, a complex that is involved in ciliogenesis regulating transport vesicles to the cilia. Further, TCP-1 theta is also involved in the folding of actin and tubulin. The intact CCT complex is composed of eight polypeptides in a double ring structure. CCT is important within cells in the folding of the VHL tumor suppressor protein.

Specifications

• Antigen: TCP-1 theta
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: CCT8
• Gene Alias: AI132397; bdav; bette davis; C21orf112; Cct8; Cctq; CCT-theta; Chaperonin containing T-complex polypeptide 1 subunit 8; chaperonin containing TCP1 subunit 8; chaperonin containing TCP1, subunit 8 (theta); chaperonin subunit 8 (theta); D21S246; fa22h09; KIAA0002; PRED71; renal carcinoma antigen NY-REN-15; T-complex protein 1 subunit theta; TCP-1-theta; Tcpq; wu:fa22h09; zgc:56059
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 10694, 12469
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 1% BSA, 20% glycerol and 0.01% thimerosal; pH 7
• Gene Accession No.: P42932, P50990
• Gene Symbols: CCT8
• Immunogen: Recombinant fragment corresponding to a region within amino acids 111 and 367 of TCP1 theta (Uniprot ID#P50990).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG