TCP-1 theta Rabbit anti-Human, Mouse, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA521689

Catalog No. PIPA521689

Description

This antibody targets TCP-1 theta in IHC (P) and WB applications and shows reactivity with Human and mouse samples. The PA5-21689 immunogen is a recombit fragment corresponding to a region within amino acids 111 and 367 of TCP1 theta (Uniprot IDNo.P50990). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.

TCP-1 theta is theta subunit of the CCT (chaperonin containing TCP1 complex) chaperonin molecule which is abundant in the eukaryotic cytosol and may be involved in the transport and assembly of the newly synthesized proteins. Molecular chaperones assist in the protein folding upon ATP hydrolysis and TCP-1 theta may play a role in the assembly of the BBsome, a complex that is involved in ciliogenesis regulating transport vesicles to the cilia. Further, TCP-1 theta is also involved in the folding of actin and tubulin. The intact CCT complex is composed of eight polypeptides in a double ring structure. CCT is important within cells in the folding of the VHL tumor suppressor protein.

Specifications

• Antigen: TCP-1 theta
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: CCT8
• Format: Liquid
• Gene Symbols: CCT8
• Immunogen: Recombit fragment corresponding to a region within amino acids 111 and 367 of TCP1 theta (Uniprot IDNo.P50990)
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Type: Antibody
• Monoclonal or Polyclonal: Polyclonal
• Target Species: Human, Mouse

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 1% BSA, 20% glycerol and 0.01% thimerosal; pH 7
• Gene Accession No.: P50990, P42932
• Gene Alias: C21orf112, Cctq, D21S246, PRED71, CCT-theta, T-complex protein 1 subunit theta, T-complex protein 1, theta subunit, TCP-1-theta, renal carcinoma antigen NY-REN-15
• Host Species: Rabbit
• Isotype: IgG
• Quantity: 100 μL
• Storage Requirements: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Primary or Secondary: Primary
• Gene ID (Entrez): 10694, 12469