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TDP-43 Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA520408

Catalog No. PIPA520408


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Description

Description

A suggested positive control is Hela cell lysate. PA5-20408 can be used with blocking peptide PEP-0525. The immunogen is located within amino acids 60 - 110 of TDP43.

TDP43 was initially identified as a novel cellular protein that bound to HIV-1 virus TAR DNA sequence motifs and acts a transcriptional repressor to the HIV-1 LTR. Later experiments revealed that TDP43 also regulates the splicing of exon 9 of the cystic fibrosis transmembrane conductance regular (CFTR), most likely through the association with the UG repeats at the 3’ splice site. A hyperphosphorylated, ubiquitinated, and cleaved form of TDP43 known as pathologic TDP43 is the major disease protein in ubiquitin-positive, tau-, and alpha-synuclein-negative frontotemporal dementia (FLTD-U). TDP43 is not related to TRBP1, and RNA binding protein that binds HIV-1 TAR RNA sequences.
Specifications

Specifications

TDP-43
Polyclonal
Unconjugated
TARDBP
Liquid
TARDBP
A 15 amino acid synthetic peptide from near the amino terminus of human TDP43
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse, Rat
Immunocytochemistry, Immunofluorescence, Western Blot
1 mg/mL
PBS with 0.02% sodium azide
Q13148, Q921F2
RP4-635E18.2, ALS10, TDP-43; TAR DNA-binding protein 43; TAR DNA-binding protein-43
Rabbit
IgG
100 μg
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Primary
230908, 23435, 298648
Documents
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