TMP21 Rabbit anti-Bovine, Human, Mouse, Non-human primate, Rabbit, Rat, Xenopus laevis, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA146005
Suggested positive control: human liver protein.TMP21 is a ubiquitously expressed protein that is involved in vesicular targeting and protein transport. More recent experiments have shown that it is also a component in the presenilin complex and modulates the gamma-secretase but not the epsilon-secretase cleavage activity of the amyloid precursor protein. The presenilin complex is composed of the proteins APH1, nicastrin, and PEN2 in addition to presenilin-1. Together, these proteins cleave the amyloid precursor protein at what is known as the gamma- and epsilon-sites and can lead to the accumulation of the Abeta cleavage product that is associated with Alzheimer’s disease. Co-immunoprecipitation experiments using antibodies against these proteins also yielded TMP21 indicating that TMP21 may play a role in the regulation of this complex. Suppression of TMP21 expression by siRNA in transfected cells caused increased gamma-secretase activity but not epsilon-secretase activity, and increased Abeta production, demonstrating that TMP21 can modulate gamma-secretase activity.
|Synthetic internal peptide corresponding to residues 50-150 of the human TMP21 protein.|
|Antigen affinity chromatography|
|Bovine, Human, Mouse, Non-human primate, Rabbit, Rat, Xenopus laevis|
|Immunohistochemistry, Western Blot|
|PBS with 30% glycerol and 0.1% sodium azide|
|Q5E971, P49755, Q9D1D4, Q28735, Q63584|
|Transmembrane emp24 domain-containing protein 10 , Transmembrane protein Tmp21 , 21 kDa transmembrane trafficking prote|
|-20° C, Avoid Freeze/Thaw Cycles|
|100009296, 10972, 379442, 529761, 68581, 84599|
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