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TopBP1 Mouse anti-Human, Unlabeled, Clone: 33, BD

Mouse Monoclonal Antibody

$232.00

Specifications

Antigen TopBP1
Isotype IgG1
Immunogen Human TopBP1 aa. 204-416
Formulation Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Conjugate Unconjugated
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Products 2
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
BDB611874
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BD Biosciences
611874
50μg
Each for $232.00
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BDB611875
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BD Biosciences
611875
150μg This item has been discontinued and is no longer available. Please call customer service for assistance: 1-800-766-7000. N/A
Description

Description

Eukaryotic DNA topoisomerase II, a ubiquitous ATP-dependent type II topoisomerase, is an essential nuclear enzyme in DNA replication and transcription, chromatin segregation, and cell cycle progression. Topoisomerases transiently break a pair of complementary strands in double-stranded DNA to form a gate for the passage of duplex DNA. Two isoforms of DNA topoisomerase II have been identified: topo IIα and topo IIβ. These exhibit a high degree of homology, except for some divergence in the C-terminal region. Both contain multiple bipartite nuclear localization sequences (NLS) that mediate their subnuclear localization. DNA Topoisomerase II Binding Protein 1 (TopBP1) binds the C-terminal region of Topo IIβ via its N-terminal region. In addition, TopBP1 contains a putative ADP-ribosylation site, two N-terminal NLS domains, and 8 repeating BRCA1 C-terminal (BRCT) domains found in DNA repair proteins, such as BRCA1, XRCC1, and Rad4. The BRCT domains of TopBP1 have been shown to bind DNA breaks, DNA nicks, and DNA termini, but not circular intact DNA. Thus, TopBP1 may localize topoisomerases to sites of DNA damage.

Host Species: Mouse
Clone: 33
Isotype: IgG1
Species Reactivity [for Features Main]: Human
Immunogen: Human TopBP1 aa. 204-416

Immunofluorescence, Western Blotting

Specifications

Specifications

TopBP1
Human TopBP1 aa. 204-416
Unconjugated
Cell Biology
Mouse
Affinity Purified
Monoclonal
Topoisomerase II Binding Protein 1
IgG1
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Primary
Western Blot
RUO
33
250μg/mL
Store undiluted at -20°C.
SDS
Product Certifications

For Research Use Only.

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