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TopBP1 Mouse anti-Human, Unlabeled, Clone: 33, BD

Catalog No. p-3850459 Shop All BD Biosciences Products
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Catalog No. Quantity
BDB611874 50 μg
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Catalog No. BDB611874 Supplier BD Biosciences Supplier No. 611874

Description

Mouse Monoclonal Antibody

Eukaryotic DNA topoisomerase II, a ubiquitous ATP-dependent type II topoisomerase, is an essential nuclear enzyme in DNA replication and transcription, chromatin segregation, and cell cycle progression. Topoisomerases transiently break a pair of complementary strands in double-stranded DNA to form a gate for the passage of duplex DNA. Two isoforms of DNA topoisomerase II have been identified: topo IIα and topo IIβ. These exhibit a high degree of homology, except for some divergence in the C-terminal region. Both contain multiple bipartite nuclear localization sequences (NLS) that mediate their subnuclear localization. DNA Topoisomerase II Binding Protein 1 (TopBP1) binds the C-terminal region of Topo IIβ via its N-terminal region. In addition, TopBP1 contains a putative ADP-ribosylation site, two N-terminal NLS domains, and 8 repeating BRCA1 C-terminal (BRCT) domains found in DNA repair proteins, such as BRCA1, XRCC1, and Rad4. The BRCT domains of TopBP1 have been shown to bind DNA breaks, DNA nicks, and DNA termini, but not circular intact DNA. Thus, TopBP1 may localize topoisomerases to sites of DNA damage.

Host Species: Mouse
Clone: 33
Isotype: IgG1
Species Reactivity [for Features Main]: Human
Immunogen: Human TopBP1 aa. 204-416

Immunofluorescence, Western Blotting

TRUSTED_SUSTAINABILITY

Specifications

Antigen TopBP1
Applications Western Blot
Classification Monoclonal
Clone 33
Concentration 250μg/mL
Conjugate Unconjugated
Description Topoisomerase II Binding Protein 1
Formulation Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Host Species Mouse
Immunogen Human TopBP1 aa. 204-416
Purification Method Affinity Purified
Quantity 50 μg
Regulatory Status RUO
Research Discipline Cell Biology
Primary or Secondary Primary
Target Species Human
Content And Storage Store undiluted at -20°C.
Isotype IgG1
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For Research Use Only.

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