TRADD Mouse, Unlabeled, Clone: 37, BD

Catalog No.	Quantity
BDB610572	50 μg

Catalog No. BDB610572 Supplier BD Biosciences Supplier No. 610572

Description

Mouse Monoclonal Antibody

TNFα (Tumor Necrosis Factor) stimulates programmed cell death and NF-κB activation as a result of its binding to the TNF receptor 1 (TNFR1). Within this receptor, a sequence referred to as the “death domain” has been shown to be necessary for both of these functions. Using the yeast two-hybrid system to detect proteins which interact with the receptor through this “death domain”, a 34kDa protein was found and designated TRADD (TNFR1-Associated Death Domain protein). TRADD appears to contain no intrinsic catalytic activity. It also contains a death domain and it has been shown to bind to FADD and RIP. Mutational analysis of TRADD demonstrates that programmed cell death and NF-κB activation are distinct and controlled independently.

Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Western Blotting

Specifications

• Antigen: TRADD
• Applications: Western Blot
• Classification: Monoclonal
• Clone: 37
• Concentration: 250μg/mL
• Conjugate: Unconjugated
• Description: TNFR1-Associated Death Domain protein
• Formulation: Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
• Host Species: Mouse
• Immunogen: Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
• Purification Method: Affinity Purified
• Quantity: 50 μg
• Regulatory Status: RUO
• Research Discipline: Cell Biology
• Primary or Secondary: Primary
• Target Species: Human, Rat
• Content And Storage: Store undiluted at -20°C.
• Isotype: IgG1

For Research Use Only.