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TRADD Mouse, Unlabeled, Clone: 37, BD

Mouse Monoclonal Antibody

Manufacturer:  BD Biosciences 610572

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Catalog No. BDB610572

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TNFα (Tumor Necrosis Factor) stimulates programmed cell death and NF-κB activation as a result of its binding to the TNF receptor 1 (TNFR1). Within this receptor, a sequence referred to as the “death domain” has been shown to be necessary for both of these functions. Using the yeast two-hybrid system to detect proteins which interact with the receptor through this “death domain”, a 34kDa protein was found and designated TRADD (TNFR1-Associated Death Domain protein). TRADD appears to contain no intrinsic catalytic activity. It also contains a death domain and it has been shown to bind to FADD and RIP. Mutational analysis of TRADD demonstrates that programmed cell death and NF-κB activation are distinct and controlled independently.

Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Western Blotting



Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Store undiluted at -20°C.
Western Blot
TNFR1-Associated Death Domain protein
Affinity Purified
Aqueous buffered solution containing BSA
Cell Biology
Human, Rat
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